Li He

Research Associate, MS in Medical Health Science

Biography

Research in structure-based drug design in small-molecule anti-HIV chemotherapeutics. Conduct bioassay involves mammalian cell culture(HEK/Hela), transfection and pseudo-virus assembling, titration of pseudo-virus, virus neutralization with compounds, cell-cell fusion assay, Pseudo-typed virus infectivity assay, Cell viability assay, ELISA, gp41 protein expression and purification from bacterial host, site-directed mutagenesis, PCR, protein binding, FPLC, and instruments management(NMR).

Research

Drug design in small-molecule anti-HIV chemotherapeutics

Recent Publications

A targeted covalent small molecule inhibitor of HIV-1 fusion / Chem. Commun., 2021,57,4528-4531