Faculty & Staff at TUC

Shin  Murakami

Shin Murakami

College: COM

Department: Basic Sciences

Title: Associate Professor

Phone: (707) 638-5903

Fax: (707) 638-5255

E-Mail: shin.murakami@tu.edu

Office: Administration & Faculty 1, Rm. 126

Dr. Murakami received his Ph.D. from Kyoto University, Japan. He then worked at University of Colorado-Boulder, University of Michigan Ann Arbor, University of Louisville, among others. His expertise includes aging, stress resistance, age-related memory impairment (AMI) and recently dementia in basic and medical sciences.  The work of aging and stress resistance has been widely accepted in the field of aging and has been repeatedly referred in manuscripts and major medical textbooks (including Harrison’s Internal Medicine; Hazzard's Geriatric Medicine and Gerontology). He has been actively mentoring students in research (10+ students per year at TUC). His areas of teaching include Med Biochemistry and Genetics (>10 years) and also a broad range of other areas (see Teaching). 

 

Current research interest is to investigate the transition of aging processes from normal aging to disease (including Alzheimer’s disease), using real-time quantitative imaging systems (Machino et al., 2014) and big data analysis in C. elegans.  He has formulated multiplex stress resistance theory of aging, which has now been extended to the middle-life crisis theory of aging.  Importantly, the “middle-life crisis” theory predicted the outcome of one or more clinical trials in the Alzheimer's disease.  He actively serves as Editorial Board Member, Grant Reviewer (AFAR, AOA and NSF), Manuscript Reviewer, and Exam Writer for the Board/NBOME (standardized exam for medical students).  He is a founding organizer/director of outreach program, Biotech Academy Touro Summer Internship, which is designed for high school and college students.  The internship uses an innovative educational approach to introduce osteopathic medicine, global health and research. It has been repeatedly highlighted by media every year since it has been started. Modified from http://www.frontiersin.org/people/ShinMurakami_1/43210/profile

 

Recent news about internship:

VALLEJO TEENS HELP WITH TOURO RESEARCH ON ALZHEIMER'S DISEASE

http://www.tu.edu/news/vth_alzheimersresearch.html

 

VALLEJO, AMERICAN CANYON STUDENTS FINISH BIOTECH INTERNSHIP AT TOURO UNIVERSITY

http://www.tu.edu/news/vth_murakami_063014.html

 

Recent papers:

Murakami, S. and Halperin, SA. (2014) Alzheimer’s patient feedback to complement research model systems using cognitive impairments. Frontiers in Genetics of Aging. Front. Genet. 5:269. doi: 10.3389/fgene.2014.00269

Highlight: This is the first paper co-authored with an AD patient in the field of model systems.

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00269/full

 

Machino, K., Link C., Wang S., Murakami, H., and Murakami, S. (2014) A semi-automated analysis of age-related memory impairment in C. elegans. Front. Genet. 5:202. doi: 10.3389/fgene.2014.00202

Highlight: Motor deficits were not well described in Alzheimer’s disease (AD). The work provides a clear evidence for motor deficits in AD model systems with neural amyloid deposits.  

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00202/abstract

Current:
Fundamentals of Osteopathic Medicine (Medical Biochemistry and Genetics, Molecular Biology, Neoplasia, Serum Protein/Vitamin/Iron, etc.)
Integrated Systems: GI (GI Biochem and Nutrition)
Integrated Systems: CVRR (Course Director) (Lipoprotein metab)
Medical Biochemistry (Course Director)
Intro to Research and Research Internship (Aging, memory impairment and dementia)
Clinical Integration


Subjects taught/served (General):
Aging, Genetics, Biochem, Molec and Cell Biology, Pathology/physiology, Clinical research, etc.

Clinical Research Basics (Course director)
Ph.D. Qualifying Exam (Director)

Topics:
Genetics and Epigenetics of Aging
AMI (Age-related Memory Impairment) and Dementia
Midlife Crisis Theory of Aging (described in Murakami et al., 2011; Murakami, 2012)

Research, Education and Community Contribution:
Biotech Academy-Touro Summer Internship (for High School Students)
Developing Aging-Osteopathic Consortium 
90 students/staffs mentored for research (10+ students per year at TUC as of July 2014). 

Service:
1. National Scientific Advisory Council, AFAR (American Federation for Aging Research)
2. Editorial Board, Review Board and Advisory Board, Frontiers in Genetics of Aging, Open Longevity Science (Formerly, The Open Aging Journal and Open Aging Review), WebmedCentral, etc.  
3. Advisory Board, Biotech Program, Vallejo High School/Hogan High School, Vallejo, CA.  
4. Reviewer for AFAR, AOA (American Osteopathic Association), NSF (National Science Foundation), and peer-reviewed journals.

Murakami lab web site (under construction)

Special Issue (Peer-reviewed)

Murakami, S. Editor (Approved by the Journal; In Progress) Biology of cognitive aging: model systems, technologies and beyond. Frontiers in Genetics.

http://www.frontiersin.org/Journal/SpecialTopicDetail.aspx?name=genetics_of_aging&st=1759&sname=Biology_of_cognitive_aging_mod

 

Invited Contribution:

Murakami, S.(2014) Diet and Exercise in Cognitive Function and Neurological Diseases, Farooqui, T. Farooqui, A. (Eds.) Wiley BlackWell, New York. Foreword.

Murakami, S. (2014) Biology of cognitive aging: model systems, technologies and beyond. Frontiers in Genetics of Aging. Editorial (See above).

 

Publications (Peer-Reviewed papers, Reviews and Book Chapters)

1. Murakami, S.and Halperin, SA. (2014) Alzheimer’s patient feedback to complement research model systems using cognitive impairments. Frontiers in Genetics of Aging. Front. Genet. 5:269. doi: 10.3389/fgene.2014.00269

Highlight: This is the first paper co-authored with an AD patient in the field of model systems.

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00269/full

2. Machino, K., Link C., Wang S., Murakami, H., and Murakami, S. (2014) A semi-automated analysis of age-related memory impairment in C. elegans. Front. Genet. 5:202. doi: 10.3389/fgene.2014.00202

Highlight: Motor deficits were not well described in Alzheimer’s disease (AD). The work provides a clear evidence for motor deficits in AD model systems with neural amyloid deposits.  

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00202/abstract

3. Murakami, S. (2013) Age-dependent modulation of learning and memory in C. elegans. In Menzel R and Benjamin P.R. (Eds.) Invertebrate Learning and Memory; Handbook of Behavioral Neuroscience.  Elsevier/Academic Press. Ch.12, Pages 140-150. Book Chapter.

Highlight: The manuscript clarifies misunderstandings in the field of AMI and describes more details of the “middle-life crisis theory of aging.”

4. Murakami, S., Cabana, K., Anderson, D.  (2011) Current advances in the study of oxidative stress and age-related memory impairment in C. elegans. In Farooqui, T. Farooqui, A.  (Ed.) Molecular aspects of oxidative stress on cell signaling in vertebrates and invertebrates, John Wiley & Sons, Hoboken, NJ. Ch 25, Pages 347-360. Book Chapter.

Highlight: The manuscript describes roles of oxidative stress in memory impairment and describes the “middle-life crisis theory of aging.”

5. Murakami, H., Bessinger, K., Hellmann, J. Luerman, G.C., Murakami, S. (2008) Serotonin as a cause of behavioral aging in C. elegans. Neurobiology of Aging. 29(7):1093-100.

Highlight: Together with Murakami and Murakami 2007, this is the first evidence for alterations in serotonin signal as a cause of early phase of aging. 

6. Murakami, H., Murakami, S. (2007) Serotonin receptors antagonistically modulate C. elegans longevity. Aging Cell. 6:483-8.

Highlight: Together with Murakami et al., 2008, this is the first evidence for alterations in serotonin signal as a cause of early phase of aging.

7. Murakami, S. (2007) C. elegans as a model system to study aging of learning and memory. Molecular Neurobiology. 35: 85-94. Review.

8. Murakami, S. (2006) Stress resistance in long-lived mice. Special Issue of Genetic Analysis of Aging. Experimental Gerontology, 41:1014-9. Review.

9. Murakami, H., Bessinger, K., Hellmann, J., Murakami, S. (2005) Aging-dependent and independent regulation of learning by insulin/IGF-1 signal in C. elegans.J. Neurosci. 25:10894-904.

10. Murakami, S. and Murakami, H. (2005) The effects of aging and oxidative stress on learning behavior in C. elegans. Neurobiology of Aging. 26:899-905.

11. Salmon, A.B., Murakami, S., Bartke, A., Kopchick, J., Yasumura, K., Miller, R.A. (2005) Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab.289: E23-9. 

12. Murakami, S., Salomon, A., and Miller, R.A. (2003) Multiplex stress resistance in cells in long-lived Dwarf mice. FASEB J. 17:1565-1566.

13. Murakami S. and Johnson T.E. (2003) Molecular genetics of longevity and stress resistance in model organisms. Current Genomics 4:63-74. Review.

14. Johnson, TE, Henderson, S., Murakami, S., de Castro, E., de Castro, S.H., Cypser, J., Rikke, B., Tedesco, P., Link, C. (2002) Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. J Inherit Metab Dis 25:197-206. Review.

15. Murakami, S. and Johnson T.E. (2001) The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Current Biology. 11:1517-1523.

16. Johnson, T.E., Cypser, J., de Castro, E., Henderson, S., Murakami, S., Rikke, B., Tedesco, P. and Link, C. (2000) Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors. Exp. Geront. 35:687-694. Review.

17. Murakami, S., Tedesco, P., Cypser, J., and Johnson, T.E. (2000) Molecular mechanism and genetic manipulation of longevity in C. elegans. Annals of NY Acad. Sci., 908:40-49. Review.

18. Rikke, B., Murakami, S., and Johnson, T. E. (2000) Molecular phylogenetics of tyrosine kinase that can extend nematode life span. Journal of Molecular Evolution.17:671-683.

19. Murakami, S. and Johnson T. E. (1998) Life extension and stress resistance modulated by the old-1 receptor tyrosine kinase gene. Current Biology. 8:1091-1094.

20. Johnson T.E., Murakami, S. Shook, D.R., Duhon, S. and Tedesco, P.M. (1997) Identifying and cloning longevity determining genes in the nematode Caenorhabditis elegans. In J.-M. Robine, J. Vaupel, Jeune and Allard (Eds.); Longevity: To the limits and beyond. Heiderberg, Springer-Verlag, pp155-163. Book Chapter.

21. Johnson, T. E., Lithgow, G. J. and Murakami, S. (1996) Hypothesis: Interventions that increase the response to stress offer the potential for effective life prolongation and increased health. J. Gerontology 51A:B392-B395.

22. Johnson, T. E., Lithgow, G. J., Murakami, S. and Shook, D. R. (1996) Genetics. In Encyclopedia of Gerontology, Academic Press, p577-586. Book Chapter.

23. Johnson, T. E., Lithgow, G. J., Murakami, S., Duhon, S. A. and Shook, D. R. (1996) Genetics of aging and longevity in lower organisms. In Holbrook, N. and Martin, G. R. (Eds.); Aging and Cell Death: Series on Modern Cell Biology, pp1-17. Book Chapter.

24. Duhon, S. A., Murakami, S. and Johnson, T. E. (1996) Direct isolation of longevity mutants in the Nematode Caenorhabditis elegans. Dev. Genet. 18:144-153.

25. Murakami, S. and Johnson T. E. (1996) A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics. 143:1207-1218.

26. Murakami, S., and Niwa, O. (1995) Fission yeast sta mutations that stabilize an unstable minichromosome are novel cdc2 interacting suppressers and are involved in spindle dynamics. Mol. Gen. Genet. 249:391-399.

27. Murakami, S., Yanagida, M., and Niwa, O. (1995) A large circular minichromosome of Schizosaccaromyces pombe requires a high dose of type II DNA topoisomerase for its stabilization. Mol. Gen. Genet 246:671-679. 

28. Takahashi, K., Murakami, S., Chikashige, Y., Funabiki, H., Niwa, O., and Yanagida, M. (1992) A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere. Molecular Biology of the Cell 3:819-835.

29. Takahashi, K., Murakami, S., Chikashige, Y., Niwa, O., and Yanagida, M. (1991) A large number of tRNA genes are symmetrically located in fission yeast centromere. Journal of Molecular Biology 218:13-17.

30. Murakami, S., Matsumoto, T., Niwa, O., and Yanagida, M. (1991) Structure of the fission yeast centromere cen3: direct analysis of the reiterated inverted region. Chromosoma 101:214-221.

31. Matsumoto, T., Murakami, S., Niwa, O., and Yanagida, M. (1990) Construction and characterization of centromeric circular and acentric linear chromosomes in fission yeast. Current Genetics 18:323-330.

32. Chikashige, Y., Kinoshita, N., Nakaseko, Y., Matsumoto, T., Murakami, S., Niwa, O., and Yanagida, M. (1989) Composite motifs and repeat symmetry in S.pombe centromeres: direct analysis by integration of Not I restriction sites. Cell 57:739-751.

College of Osteopathic Medicine (Faulty)

Master of Sciences in Medical Health Sciences/COM (Founding faculty)

Biotech Academy Touro Internship Program (Founding organizer/Director)

  Program in the news: http://www.tu.edu/news/vth_alzheimersresearch.html

 

Associations/Initiatives:

Alzheimer's Association

Alzheimer's Prevention Initiative

Gerontology Society of America

Genetics Society of America

ResearchersAgainstAlzheimers.org

Last Updated: 12/5/14