Faculty & Staff at TUC

Shona Mookerjee

Shona Mookerjee

College: COP

Department: Biological & Pharmaceutical Sciences

Title: Assistant Professor

Phone: (707) 638-5922

Fax: (707) 638-5959

E-Mail: shona.mookerjee@tu.edu

Office: Administration and Faculty 2, Rm. 215

B.A., Biology and Environmental Science, Carleton College, 2000

Ph.D., Molecular Genetics, University of Rochester, 2006

Track 2: Pharmaceutical Sciences

Mitochondrial energetics and maintenance

Co-investigator (with Maggie Louie, lead PI), NIH R15 Award: “Prolonged cadmium exposure promotes oxidative stress-dependent transcription and breast cancer progression” R15ES025917-01A1

2018    Gunter, A., Gerencser, A.A., Phuong, L., Bornstein, S., Mookerjee, S.A., Maridas, D., Brand, M.D., Rosen, C. Metabolic Programming of Mesenchymal Progenitor Cells Characterize Lineage Allocation. Journal of Bone and Mineral Research 2018 Jan 17. doi: 10.1002/jbmr.3390. [Epub ahead of print]

2017   Gerencser, A.A*, Mookerjee, S.A*., Jastroch, M., Brand, M.D. Positive Feedback Amplifies the Response of Mitochondrial Membrane Potential to Glucose Concentration in Clonal Pancreatic Beta Cells. Biochimica et Biophysica Acta 1863(5): 1054-1065 (doi: 10.1016/j.bbadis.2016.10.015. published online 2016 Oct 20)

                        *These authors contributed equally

2017   Mookerjee, S.A., Gerencser, A.A., Nicholls, D.G., Brand, M.D. Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements. Journal of Biological Chemistry 292(17): 7189-7207


2017   Nguyen, L., Lucke-Wold, B.P., Mookerjee, S.A., Kaushal, N., Matsumoto, R.R. Sigma-1 receptors and neurodegenerative diseases: Towards a hypothesis of sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection. Advances in Experimental Medicine and Biology 964:133-152. doi: 10.1007/978-3-319-50174-1_10.


2016   Gerencser, A.A, Mookerjee, S.A.,  Jastroch, M., Brand, M.D. Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells, PLoS ONE 11(7): e0159199.


2016   Mookerjee, S.A., Nicholls, D.G., Brand, M.D. Determining maximum glycolytic capacity using extracellular flux measurements. PLoS ONE 11(3): e0152016. doi:10.1371/journal.pone.0152016


2015    Guyenet, S., Mookerjee, S., Lin, A., Custer, S.K., Chen, S.F., Sopher, B.L., LaSpada, A.R., and Ellerby, L.M.Proteolytic Cleavage of Ataxin-7 Promotes SCA7 Retinal Degeneration and Neurological Dysfunction. Human Molecular Genetics 2015, 24:3908-3917 (doi: 10.1093/hmg/ddv121. Published online April 2015)


2015     Mookerjee, S.A., Brand, M.D. Measurement and analysis of extracellular acid production to determine glycolytic rate. In press, Journal of Visualized Experiments (106), e53464, doi:10.3791/53464


2014     Nguyen, L., Lucke-Wold, B.P., Mookerjee, S.A., Cavendish, J.Z., Robson, M.J., Scadinaro, A.L., Matsumoto, R.R. Role of sigma-1 receptors in neurodegenerative disease. Journal of Pharmacological Sciences 2015, 127:17-29 (doi:10.1016/j.jphs.2014.12.005; published online December 2014)


2014     Mookerjee, S.A., Goncalves, R.L., Gerencser, A.G., Nicholls, D.G., Brand. M.D. The contributions of respiration and glycolysis to extracellular acid production. Biochim Biophysica Acta 2015, 1847:171-181 (Published online October 2014, http://dx.doi.org/10.1016/j.bbabio.2014.10.005)


2013     Mookerjee, S.A., Sia, E.A. Using genetic reporters to assess stability and mutation of the yeast mitochondrial genome. Directed Mutagenesis 2013 ISBN 979-953-307-450-3 InTech Publishing


2011    Mookerjee, S.A., Brand, M.D. Characteristics of the turnover of uncoupling protein 3 by the ubiquitin proteasome system in isolated mitochondria. Biochim Biophys Acta. 2011. 1807: 1474-81


2010    Brand, M.D., Parker, N.,  Affourtit, C., Mookerjee, S.A., Azzu, V. Mitochondrial uncoupling protein-2 in pancreatic beta cells. Diabetes Obes Metab. 2010: Suppl 2:134-40


2010    Mookerjee, S.A., Divakaruni, A., Jastroch, M., Brand, M.D. Mitochondrial uncoupling and lifespan. Mech Ageing Dev. 2010. 131: 463-72


2010    Jastroch, M., Divakaruni, A., Mookerjee, S., Treberg, J., Brand, M.D. Mitochondrial Proton and Electron Leaks. Essays Biochem. 2010. 47: 53-67


2010    Azzu, V*., Mookerjee, S.A*., Brand, M.D. Rapid Turnover of Mitochondrial Uncoupling Protein 3. Biochem J. 2010. 426: 13-7

            *These authors contributed equally

2010    Guyenet, S.J., La Spada, A.R., Mookerjee, S.A., Lin, A., Custer, S.K., Chen, S., Sopher, B.L., Ellerby, L.M. Proteolytic Cleavage of Ataxin-7 is Required for SCA7 Retinal Degeneration and Neurological Dysfunction" (Submitted for publication, JN-RM-4725-09)


2009    Mookerjee, S., Papanikolaou, T., Guyenet, S., Sampath, V., Lin, A., Vitelli, C., DeGiacomo, F., Sopher, B., Chen, S., La Spada, A., Ellerby, L. Post-translational modification of ataxin-7 at lysine-257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment" J Neurosci. 2009 29:15134-44


2009    Pogorzala, L., Mookerjee, S.A., Sia, E.A. A role for Msh1p in mitochondrial base excision repair Genetics 2009. 182: 699-709


2006    Mookerjee, S.A., Sia, E.A. Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae. Mutation Research 2006. 595: 91-106


2005    Mookerjee, S.A., Lyon, H., Sia, E.A. Analysis of the functional domains of the mismatch repair homolog, Msh1p and its role in mitochondrial genome maintenance. Current Genetics 2005. 47: 84-99.

2016-present             Member, American Physiological Society

2016-present             Member, American Society for Biochemistry and Molecular Biology

2015-present             Member, Society for Redox Biology and Medicine

2017                Co-investigator (with Karl Meszaros), Touro-CA IRAP: The effect of fructose on energy metabolism and substrate utilization in liver cells

2016                Co-investigator (with Maggie Louie, lead PI), NIH R15 Award: “Prolonged cadmium exposure promotes oxidative stress-dependent transcription and breast cancer progression” R15ES025917-01A1

2015                Best Professor, College of Pharmacy Class of 2017

2010                California Institute for Regenerative Medicine Research Training Award: “Dynamic regulation of UCP2 in multipotent stem cells” TG2-101155

2009                NIH U54 Pilot Project Award: “Mapping ubiquitination sites of the mitochondrial uncoupling proteins UCP2 and UCP3” under “Mass spectrometry and imaging technologies in Geroscience” 1PL1AG032118-01

2007-2008       NIH T32 Training Award AG000266

2000                SURE Internship award, Gulf of Maine Foundation

1996-2000       James J. Kerrigan Memorial Scholarship, Merck and Co.

Touro University College of Pharmacy

Assistant Professor

Biological and Pharmaceutical Sciences

2013-present

 

Buck Institute for Research on Aging

Adjunct Assistant Professor

2013-present

Last Updated: 5/4/18