Faculty & Staff at TUC

Alan Miller

College: COM

Department: Basic Sciences, MSMHS

Title: Professor

Phone: (707) 638-5235

Fax: (707) 638-5255

E-Mail: alan.miller@tu.edu

Office: Administration & Faculty 1, Rm. 135

Institution Degree Field of Study Obtained
University of California, Irivine Ph.D. Physiology/Biophysics 1992
New York Unversity M.S. Physics 1986
Brown University B.S. Physics 1984

Teaching

Fall Semester: Neurophysiology (DO program and MSMHS program), Cardiovascular Physiology (MSMHS program)

Spring Semester: Cardiovascular Physiology (DO program), Renal Physiology (DO program). Cardiovascular Physiology (PA program)

Research Interests

The research in my laboratory focuses on the voltage-gated potassium channel HERG (Human-ether-a-go-go related gene) which is responsible for the repolarization of the cardiac action potential in cardiac myocytes.  Reduction of HERG channel numbers by a variety  of different mechanisms including block by pharmaceutical agents or a number of extracellular electrolytes, as well as mutations in the gene encoding the HERG channel, can cause long QT syndrome.  In some rare cases long QT syndrome can degenerate into ventricular fibrillation which can be lethal. 

The research focuses on studying:

  1. the mechanisms by which a number of different drugs block HERG
  2. the effects of extracellular electrolytes (such as calcium, magnesium, and hydrogen) on the HERG channel
Last Updated: 7/16/14