Faculty & Staff at TUC

Karl  Meszaros

Karl Meszaros

College: COP

Department: Biological & Pharmaceutical Sciences

Title: Professor

Phone: (707) 638-5244

Fax: (707) 638-5959

E-Mail: karl.meszaros@tu.edu

Office: Administration & Faculty 2, Rm. 204

Institution Degree Field of Study Obtained
Semmelweis University, Budapest M.D. Medicine 1971
Semmelweis University, Budapest Ph.D Biology 1978

Biology, Pathophysiology 

Carbohydrate and fat metabolism 

1. Mészáros K, Antoni F, Hrabák A, Szikla C, Garzó T, Tompa A, Lapis K. Prevention of the hepatotoxic effects of D-galactosamine by D-galactose. FEBS Lett. 1973;35(1):1-3. 
2. Mészáros K, Antoni F, Mandl J, Hrabák A, Garzó T. Effects of D-galactosamine on nucleotide metabolism and microsomal membranes in mouse liver. FEBS Lett. 1974;44(2):141-5. 
3. Mészáros K, Mandl J, Antoni F, Garzó T. Inhibition of protein synthesis by hexosamine containing glycogen formed in mouse liver after treatment with D-galactosamine. FEBS Lett. 1976;71(2):215-9. 
4. Tompa A, Lapis K, Schaff Z, Mészáros K, Mandl J, Garzó T, Antoni F. Cytoplasmic aggregates in D-galactosamine induced liver injury. Acta Morphol Acad Sci Hung. 1977;25(4):239-57. 
5. Mandl J, Garzó T, Mészáros K, Antoni F. Epinephrine and glucagon counteract inhibition of protein synthesis induced by D-galactosamine in isolated mouse hepatocytes. Biochim Biophys Acta. 1979;586(3):560-7. 
6. Mészáros K, Chance B, Holtzer H. Myoglobin and cytochrome oxidase in the myocardium of the developing chick. J Mol Cell Cardiol. 1980;12(10):965-75. 
7. Tihanyi K, Mészáros K, Horváth I. Inhibition of microsomal drug metabolism by mitochondria and cytochrome c oxidation of extramitochondrial NADPH. Biochem Pharmacol. 1982;31(5):661-3. 
8. Mandl J, Mészáros K, Antoni F, Spolarics Z, Garzó T. Reversible inhibition of RNA synthesis and irreversible inhibition of protein synthesis by D-galactosamine in isolated mouse hepatocytes. Mol Cell Biochem. 1982;46(1):25-30. 
9. Puskás M, Antoni F, Péterfy F, Mészáros K. Pokeweed mitogen, Bordetella pertussis and breast milk cell factor induce preferentially the synthesis of different immunoglobulin classes. Boll Ist Sieroter Milan. 1983;62(3):262-7. 
10. Krasznai A, Arányi P, Fehér T, Krajcsi P, Mészáros K, Horváth I. Alterations in the number of glucocorticoid receptors of circulating lymphocytes in sepsis. Haematologia (Budapest). 1986;19(4):293-8. 
11. Krasznai A, Krajcsi P, Arányi P, Mészáros K, Horváth I. Decreased number of steroid receptors of circulating lymphocytes in Crohn'sdisease and ulcerative colitis. Haematologia (Budapest). 1986;19(4):299-301. 
12. Mészáros K, Bagby GJ, Lang CH, Spitzer JJ. Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats. Am J Physiol. 1987;253(1 Pt 1):E33-9. 
13. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. Contribution of different organs to increased glucose consumption after endotoxin administration. J Biol Chem. 1987;262(23):10965-70. 
14. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues. Biochem Biophys Res Commun. 1987;149(1):1-6. 
15. Spitzer JJ, Bagby GJ, Mészáros K, Lang CH. Alterations in lipid and carbohydrate metabolism in sepsis. JPEN J Parenter Enteral Nutr. 1988;12(6 Suppl):53S-58S. 
16. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis. FASEB J. 1988;2(15):3083-6. 
17. Spitzer JJ, Bagby GJ, Meszaros K, Lang CH. Altered control of carbohydrate metabolism in endotoxemia. Prog Clin Biol Res. 1989;286:145-65. 
18. Spitzer JJ, Bagby GJ, Hargrove DM, Lang CH, Mészáros K. Alterations in the metabolic control of carbohydrates in sepsis. Prog Clin Biol Res. 1989;308:545-61. 
19. Mészáros K, Lang CH, Bojta J, Spitzer JJ. Early changes in glucose utilization of individual tissues after endotoxin administration. Circ Shock. 1989;29(2):107-14. 
20. Mészáros K, Lang CH, Hargrove DM, Spitzer JJ. Tissue glucose utilization during epinephrine-induced hyperglycemia. J Appl Physiol. 1989;67(5):1770-5. 
21. de Boisblanc BP, Meszaros K, Cairo J, Spitzer JJ, Summer W. Diaphragmatic fatigue after endotoxemic shock in rats: in vitro function and metabolism. J Med. 1990;21(1-2):7-26. 
22. Bautista AP, Mészáros K, Bojta J, Spitzer JJ. Superoxide anion generation in the liver during the early stage of endotoxemia in rats. J Leukoc Biol. 1990;48(2):123-8. 
23. Lang CH, Dobrescu C, Mészáros K. Insulin-mediated glucose uptake by individual tissues duringsepsis. Metabolism. 1990; 39(10):1096-107. 
24. Mészáros K, Bojta J, Bautista AP, Lang CH, Spitzer JJ. Glucose utilization by Kupffer cells, endothelial cells, and granulocytes in endotoxemic rat liver. Am J Physiol. 1991;260(1 Pt 1):G7-12. 
25. Spolarics Z, Schuler A, Bagby GJ, Lang CH, Mészáros K, Spitzer JJ. Tumor necrosis factor increases in vivo glucose uptake in hepatic nonparenchymal cells. J Leukoc Biol. 1991;49(3): 309-12. 
26. Mészáros K. Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads. Biochem Biophys Res Commun. 1991;180(1):315-22. 
27. deBoisblanc BP, Meszaros K, Burns A, Bagby GJ, Nelson S, Summer WR. Effect of dichloroacetate on mechanical performance and metabolism of compromised diaphragm muscle. J Appl Physiol. 1992;72(3):1149-55. 
28. Mészáros K, Parent JB, Gazzano-Santoro H, Little R, Horwitz A, Parsons T, Theofan G, Grinna L, Weickmann J, Elsbach P, et al. A recombinant amino terminal fragment of bactericidal/permeability-increasing protein inhibits the induction of leukocyte responses by LPS. J Leukoc Biol. 1993;54(6):558-63. 
29. Elsbach P, Weiss J, Doerfler M, Shu C, Kohn F, Ammons WS, Kung AH, Meszaros K, Parent JB. The bactericidal/permeability increasing protein of neutrophils is a potent antibacterial and anti-endotoxin agent in vitro and in vivo. Prog Clin Biol Res. 1994;388:41-51. 
30. Theofan G, Horwitz AH, Williams RE, Liu PS, Chan I, Birr C, Carroll SF, Mészáros K, Parent JB, Kasler H, et al. An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity. J Immunol. 1994;152(7):3623-9. 
31. Gazzano-Santoro H, Mészáros K, Birr C, Carroll SF, Theofan G, Horwitz AH, Lim E, Aberle S, Kasler H, Parent JB. Competition between rBPI23, a recombinant fragment of bactericidal/permeability-increasing protein, and lipopolysaccharide (LPS)-binding protein for binding to LPS and gram-negative bacteria. Infect Immun. 1994;62(4):1185-91. 
32. Mészáros K, Aberle S, Dedrick R, Machovich R, Horwitz A, Birr C, Theofan G, Parent JB. Monocyte tissue factor induction by lipopolysaccharide (LPS): dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein. Blood. 1994;83(9):2516-25. 
33. Mészáros K, Aberle S, White M, Parent JB. Immunoreactivity and bioactivity of lipopolysaccharide-binding protein in normal and heat-inactivated sera. Infect Immun. 1995;63(1):363-5. 
34. Luo J, Chuang T, Cheung J, Quan J, Tsai J, Sullivan C, Hector RF, Reed MJ, Meszaros K, King SR, Carlson TJ, Reaven GM. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Eur J Pharmacol. 1998;346(1):77-9. 
35. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Brignetti D, Luo J, Khandwala A, Reaven GM. Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999;42(1):1026. 
36. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, Reaven GM. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism. 2000;49(11):1390-4. 
37. Antoni F., and K. Mészáros. Immunopeptides, peptide antigens. In: Biomedical Significance of Peptide Research. Eds. F. Laszlo and F. Antoni. Publishing House of the Hungarian Academy of Sciences, Budapest, p. 115-125, 1984. 
38. Spitzer, J. J., G. J. Bagby, D. M. Hargrove, C. H. Lang, and K. Mészáros. Alterations in the metabolic control of carbohydrates in sepsis. In: Progress in Clinical Biological Research. Eds. E. Schlag and H. Redl. A. R. Liss, New York, 308: 545-561, 1989. 
39. Spitzer, J. J., J. Bojta, C. H. Lang, and K. Mészáros. Cellular metabolic responses in endotoxemia and a hypothesis for the mechanism of hepatic failure in endotoxin shock. In: Shock, Trauma, Sepsis and Organ Failure. Eds G. Schlag, H. Reidl, J. H. Siegel. Springer Verlag, New York. p. 278-303, 1990. 
40. Spitzer, J. J., K. Mészáros, A. Bautista, C. H. Lang, and Z. Spolarics. Potential contribution of phagocytic cells to liver damage after E. coli endotoxin. In: Cellular and Molecular Aspects of Endotoxin Reactions. Vol. 1. Eds A. Novotny, J. J. Spitzer, and E. J. Siegler. Elsevier, New York, p. 521-528, 1990. 
41. Spitzer, J. J., Z. Spolarics, A. P. Bautista, K. Mészáros, A. Schuler, and C. H. Lang. Increased glucose uptake and superoxide anion production after priming or activation of hepatic phagocytes: a potential source of liver damage. In: Shock, Trauma, Sepsis and Organ Failure. Eds G. Schlag, H Reidl, J. H. Siegel, and D. L. Traber. Springer Verlag, New York. p. 235-249, 1991. 
42. Conlon, P. J., H. Gazzano-Santoro, K. Mészáros, R. Little, K. Huang, J. Watkins, S. Aberle, H. Kasler, D. Fishwild, G. Theofan, A, Horwitz and J. B. Parent. rBPI23: A potent bactericidal and anti-endotoxin agent. In: Mediators of Sepsis. Eds J.-D. Baumgartner, T. Calandra, J. Carlet. Medicine-Sciences Flammarion, Paris. p. 23-35, 1993. 
43. Elsbach, P., J. Weiss, M. Doerfler, C. Shu, F. Kohn, W. S. Ammons, A. H. C. Kung, K. Mészáros, J. B. Parent, H. Gazzano-Santoro, K. Huang, and D. Fishwild. The bactericidal/permeability increasing protein of neutrophils is a potent antibacterial and anti-endotoxin agent in vitro and in vivo. In: Bacterial Endotoxins. Basic Science to Anti-Sepsis Strategies. Eds Levin, J., van Deventer, S. J .H., van der Poll, T., and Sturk, A. Wiley-Liss, New York, p. 41-51, 1994. 

44. Mészáros, K., K. Huang, H. Gazzano-Santoro, R. Dedrick, and J. B. Parent. Inhibition of the effects of LPS on endothelial cells by rBPI21 Cys, a recombinant fragment of bactericidal/permeability increasing protein. In: Immune consequences of Trauma, Sepsis and Endotoxicosis. Ed. Faist, J. Springer, Berlin, Heidelberg, New York, p. 146-154, 1996. 
45. Mészáros, K., M. Barnett, H. Wehring, D. Evans, D. Sasaki-Hill, P. Goldsmith, and K. Knapp. Progress examination for assessing students’ readiness for advanced pharmacy practice experiences. Am J of Pharm Educ, Vol 73, Issue 6, Article 109, 2009 

46. Mészáros K, Lopes IC, Goldsmith PC, Knapp KK. Interprofessional education: cooperation among osteopathic medicine, pharmacy, and physician assistant students to recognize medical errors. J Am Osteopath Assoc. 2011 Apr;111(4):213-8. PubMed PMID: 21562289.

47. Meszaros, K., Barnett, M. J., Lenth, R. V., & Knapp, K. K. (2013). Pharmacy school survey standards  revisited. Am J Pharm Educ, 77(1), 3. doi: 10.5688/ajpe7713

48.Alternative Viewpoint: Preparation for Residency. Katherine K. Knapp, Károly Mészáros, Paul C. Goldsmith, Gordon C. McCarter, Elizabeth Kelly Hester, et al.  Pharmacotherapy  2014; 34(8):e157–e158; doi: 10.1002/phar.1475

Employer Title From - To
Touro University - California Associate Professor, then Professor 1999 - present
XOMA Corporation, Berkeley, CA Senior Scientist 1991
Louisiana State University, Department of Physiology, New Orleans Assistant Professor 1985
Last Updated: 3/15/16