Faculty & Staff at TUC

Maggie Louie

College: COP

Department: Biological & Pharmaceutical Sciences

Title: Associate Professor

Phone: (707) 638-5989

Fax: (707) 638-5266

E-Mail: maggie.louie@tu.edu

Office: Administration & Faculty 2, Rm. 211

Institution Degree Field of Study Obtained
University of California, Berkeley B.S. Biochemistry and Molecular Biology 1997
University of California, Berkeley B.A Nutritional Science 1997
San Francisco State University, San Francisco M.S Chemistry, Emphasis in Biochemistry 2000
University of California, Davis Ph.D Biochemistry and Molecular Biology 2004
UC Davis Cancer Center Post-Doc Cancer Biology 2005

Fall:
PHRM 610: Pharmaceutical Science (Participating Faculty Member) 

Spring:
PHRM 614: Pharmaceutical Science (Participating Faculty Member) 

Preceptor for MSMHS-COP students

Breast cancer is one of the most common malignancies that occur in women in the United States. Breast cancer results from the abnormal proliferation of the cells in the mammary gland. The normal growth of mammary gland epithelial cells is modulated by the circulating levels of estrogen, a hormone produced by the ovaries. The activity of estrogen is mediated by the estrogen receptor (ER) and thus serves as a key prognostic marker in breast cancer development. Breast cancer exists as either estrogen responsive or estrogen non-responsive cancer. Majority of breast cancer initially develops as hormone dependent-cancer in which the growth and progression of the cancer is modulated by the action of estrogen. Hormone responsive cancer is typically treated with hormone ablation therapy or endocrine therapy to block the ER. Although success has resulted from such treatments, the cancer often develops into a more aggressive, hormone independent phenotype. The mechanism of how hormone independence develops is unclear and the role of ER in this process remains to be determined. In addition to understanding how hormone refractory breast cancer develops, my lab is also interested examining the role of metalloestogens in the development and progression of the disease.

1. National Institutes of Health-AREA Grant (R15) 2R15CA121983-01 Chronic cadmium promotes breast cancer progression (PI: Louie) 08/01/2010-07/31/2014 $350,000 

2. National Science Foundation-Major Research Instrumentation (NSF-MRI) Acquisition of Molecular Imager for Undergraduate Research (PI: Louie) 08/01/2010-07/31/2012 $66,798 

3. National Science Foundation- Genomic Consortium for Active Teaching Minigrant (PI: Johnson-Brousseau, Co-PI: Louie) 01/20/ 2010 $18,000 

4. National Institutes of Health-AREA Grant (R15) 1R15CA121983-01A1 (PI: Louie).
Understanding the role of Cadmium in ER+ Breast Cancer Cell Proliferation 09/01/2007-08/31/2010 $206,000 

5. National Institutes of Health-Research Supplement to Promote Diversity 1R15CA121983-01A1 S1 (PI: Louie) Understanding the role of Cadmium in ER+ Breast Cancer Cell Proliferation 03/01/2008-05/31/2010 $53,106

6. Wendy Will Case Cancer Fund (PI: Louie) The role of cadmium in ER+ Breast Cancer Cell Proliferation 01/01/2007- 12/31/2007 $30,000 

7. Turner BioSystems Luminometer Grant (PI: Louie) 06/01/2005 $5,000 

 Peer-Reviewed Publications:

  • Ponce, E. Louie, M.C., and Sevigny, M.B. Acute and Chronic Cadmium Exposure Promotes E-Cadherin Degradation in MCF7 Breast Cancer Cells. Molecular Carcinogenesis. Published online-Early View onMay 2014
  • Lubovac-Pilav, Z. Borràs, D.M. Ponce, E. Louie, M.C. Using Expression Profiling to Understand the Effects of Chronic Cadmium Exposure on MCF-7 Breast Cancer Cells. PLoS ONE 2013 8(12): e84646.
  • Ponce, E., *Aquino, N.B. and Louie, M.C. Chronic exposure to cadmium promotes breast cancer progression by stimulating the expression SDF-1.  PLoS ONE 2013 8(8): e72639
  • Vaksman, N., Barnett, M., Hakobyan, L., Kucher, I., Louie, M.C. The Impact of Incorporating Pharmacogenomics into the Pharmacy Curriculum on Student Interest. Pharmacy Education 2012 12(1): 31-36  
  • Aquino, N.B., Sevigny, M.B., *Sabangan, J., Louie, M.C.The Role of Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or Not? Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Review 2012 30(3): 189-224
  • Cyclooxygenase-2 (COX-2) decreases the efficacy of certain COX-2 inhibitors. Sevigny, M.B., *Graham, K., *Ponce, E., Louie, M.C. and *Mitchell, K. Pharmacological Research 2012 65(4):445-50
  • Siewit, C.L., *Gengler, B., *Vegas, E., *Puckett, R., Louie, M.C., Cadmium promotes breast cancer cell proliferation by mediating the interaction between ERa and c-jun. Molecular Endocrinology 2010 24(5):981-992
  • Louie, M.C., *McClellan, A., *Siewit, C.L., *Kawabata, L. Estrogen Receptor Regulates the Expression of E2F1 to Mediate Tamoxifen Resistance. Molecular Cancer Research 2010 8:343-352
  • Li, L., Louie M.C., Chen H.W., Zou, J. Proto-oncogene ACTR/AIB1 promotes breast cancer cell invasion by up-regulating specific MMP expression. Cancer Letters 2008 Mar 8;261(1):64-73
  • Fussell, J. and Louie, M.C. The Impact of the Golden Gate Bridge on Marin County Suicide Statistics. BIOS 2008 79(4) 171-178
  • Louie M.C., Revenko, A., Yao, J., Zou, J., Chen H.W. Direct Control of Cell Cycle Gene Expression by Proto-Oncogene Product ACTR, and Its Autoregulation Underlies Its Transforming Activity MCB 2006. 26:3810-3823
  • Louie M.C., Zou J.X., Rabinovich, A., Chen H.W. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and anti-estrogen resistance. MCB 2004. 24:5157-5171
  • Louie M.C.,Yang Q.H., Ma A.H., Zou J.X., Kung H.K., Chen H.W. Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. PNAS 2003. 100(5): 2226-223
  • Lee L.F*., Louie M.C.*, Yang J., Desai S., Evans C.P., Chen H.W., Kung, H.J. Interleukin 8 confers androgen independent growth an d migration in LNCaP: Differential Effects of Tyrosine Kinases Src and FAK. Oncogene 2004. 1-9 
  • Louie M.C., Kondor N., and DeWitt J.G. Gene expression in cadmium-tolerant Datura innoxia: detection and characterization of cDNAs induced in response to Cd2+ Plant Molecular Biology. Plant Molecular Biology 2003. 51(1): 81-89

 

 

 

 

 

2009-present American Association for Colleges of Pharmacy-Active Member 
2008-Present American Association for Biochemistry and Molecular Biology 
2008-Present American Association for Cell Biology-Member 
2008-Present Department of Defense-Breast Cancer Program-Grant Reviewer 
2006-Present Komen Foundation-Grant Reviewer 
2006-Present American Association for Cancer Research-Member 
2006-Present Scientific Journal International-Editorial Board Member 
2005-Present Council for Undergraduate Research-Member 

2013 Teacher of the Year at Dominican University 
2009 Genomic Consortium for Active Teaching Workshop grant 
2007 100+ Magnificent Women in Marin 
2006-2007 Scholarship of Research Award (Dominican University) 
2005-2006 Academic Excellence Award (Dominican University) 
2004 Keystone Travel Scholarship 
2001-2004 NIH-MCB-Training Grant 
1999-2000 GAANN Fellowship 

Employer Title From - To
Dominican University, Department of Natural Sciences Associate Professor 2005-now
Touro University – California / College of Pharmacy Associate Professor-Part time 2006-now
Last Updated: 3/15/16