Faculty & Staff at TUC

Dr. Shengquan  Liu

Shengquan Liu

College: COP

Department: Biological & Pharmaceutical Sciences

Title: Associate Professor

Phone: (707) 638-5983

Fax: (707) 638-5255

E-Mail: shengquan.liu@tu.edu

Office: Administration & Faculty 2, Rm. 207

Institution Degree Field of Study Obtained
Shenyang Pharmaceutical University B.S., M.S Pharmacy 1982
The University of Louisiana at Monroe Ph.D. Medicinal Chemistry 1997
Oklahoma State University Postdoc Medicinal Chemistry 1999
The University of Texas at Austin Postdoc Medicinal Chemistry 2001

Fall Semester 
PHRM 602: Pharmaceutical Sciences (Participating Faculty Member) 
PHRM 610: Pharmaceutical Sciences (Participating Faculty Member) 
Spring Semester 
PHRM 606: Pharmaceutical Sciences (Participating Faculty Member) 
PHRM 614: Pharmaceutical Sciences (Participating Faculty Member) 

Intramural Grants - Funded

Touro University Intramural Grant (2008) for Design, Synthesis and Pharmacological Evaluation of Polar SHetA2 analogs as Novel Anti-cancer Agents.  ($ 20,000.00)

Touro University Intramural Research Award Program (IRAP) (2011) for Mechanism of Action of Novel Thiourea Anticancer agents.  ($ 4,554.00) 

PATENTS: 

US Patent: Tocopherols, Tocotrienols, Other Chroman and and Side Chain Derivatives and Uses Therof. Bob G. Sanders; Kimberly Kline; Laurence Hurley; Robb Gardner; Marla Menchaca; Weiping Yu; Puthucode N. Rammanan ; Shengquan Liu; Karen Israel 

US Patent: 6,417,223 B1 (2002) 
US Patent: 2002/0156024 A1, 2002 
US Patent: 6,645,998, 2003 
US Patent: 6,770,672 B1, 2004 
US Patent: 2004/0235938 A1, 2004 
US Patent: 73112232, 2007 
US Patent: 20080119514, 2008 
EP 1115398 EP1115398 and WO0016772

SELECTED PUBLICATIONS: 

Shengquan Liu, Maggie C. Louie, Vanishree, Rajagopalan, Guangyan Zhou, Esmeralda Ponce, Tran Nguyen, and Linda Green.  Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents.  Bioorganic & Medicinal Chemistry Letter .  Accepted.

Lin Y, Chen S, Yue P, Zou PW, Benbrook DM, Liu S, Le TC, Berlin KD, Khuri FR, Sun S-Y. CHOP-Dependent upregulation of death receptor 5 is a major component of apoptotic cell death induced by the flexible heteroarotinoid SHetA2 in human lung cancer cells. Cancer Research. 2008; 68 (13): 5335-44. 

Norman BH, Richardson TI, Dodge JA, Pfeifer LA, Durst GL, Wang Y, Durbin JD, Krishnan V, Dinn SR, Liu S, Reilly JE, Ryter KT. Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring. Bioorg Med Chem Lett. 2007; 17 (18): 5082-5 

Liu S, Brown CW, Berlin KD, Dhar A, Guruswamy S, Brown D, Benbrook DM. Synthesis of flexible sulfur-containing heteroarotinoids that induce apotosis and reactive oxygen species with discrimination between malignant and benign cells. J Med Chem. 2004; 47, 999-1007. 

Brown CW, Liu S, Klucik J, Berlin KD, Brennan PJ, Kaur D, Benbook DM. Novel heteroarotinoids as potential antagonists of mycobacterium bovis BCG. J Med Chem. 2004; 74, 1008-17. 

Crider AM, Liu S, Li T, Mahajan S, Ankersen M, Stidsen C E. Somatostatin receptor subtype 4(sst4) ligands: synthesis and evaluation of indol-3-yl-and 2-pyridyl-thioureas. Lett Drug Des discov. 2004; 1, 84-7. 

Liu S, Berlin KD, Simms-Kelly MD, Nelson EC, Benbrook D M. Optimization and synthesis of (E)-4-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-1-propenyl]benzoic acid-11-[14C]. J Label Compds RadioPharm. 1999: 42, 789-96. 

Dhar A, Liu S, Berlin KD, Madler MM, Birckbichler PJ, Lu S, Ivey TT, Zacheis D, Brown DW, Klucik J, Nelson EC, Benbrook DM. Synthesis and structure-activity relationships and RAR-ligand interaction of nitrogen heteroarotinoids. J Med Chem. 1999; 42, 3602-14. 

Liu S, Crider AM, Tang C, Ho B, Ankersen M, Stidsen CE. Novel non-peptide somatostatin agonists with sst4 selectivity. Curr Pharm Des. 1999; 5, 255-63 

Zacheis D, Dhar A, Lu S, Madler MM, Klucik J, Brown CW, Liu S, Clement F, Subramanian S, Weerasekare GM, Berlin KD, Gold MA, Houch JRJr, Fountain KR, Benbrook DM. Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem. 1999, 42, 4434-45. 

Liu S, Ho B, Tang C, Ankersen M, Stidsen C, Crider M. Non-peptide somatostatin agonists with sst4 selectivity: Synthesis and structure activity relationships of thioureas. J Med Chem 1998; 41, 5693-705. 

Ankersen M, Crider M, Liu S, Ho B, Andersen HS, Stidsen C. Discovery of a novel non-peptide somatostatin agonist with sst4 selectivity. J Am Chem Soc. 1998; 120, 1360-73. 

Benbrook DM, Subramanian S, Gale JB, Liu S, Bown CW, Boehm MF, Berlin KD. Synthesis and characterization of heteroarotinoids demonstrate structure-specificity relationships. J Med Chem. 1998; 41, 3753-7. 

Medler MM, Klucik J, Soell PS, Brown CW, Liu S, Berlin KD, Benbrook DM, Birckbichler PJ, Nelson EC. Lithium hypochlorite-clorox as a novel oxidative mixture for methyl ketones and methyl carbinols. Org Prep Proced Int. 1998; 30, 230-4. 

Liu S, Pezzuto JM, Kinghorn AD. Additional biologically active constituents of the chinese tallow tree. J Nat Prod. 1988; 51, 619-21. 


BOOK CHAPTERS: 

Liu S. Central nervous system depressants. Chapter 12. In: Block JH, Beale JM, editors. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th ed. Philadephia: Lippincott Williams & Wilkins. 2010. p. 443-470. 

Liu S. Adrenergic agents. Chapter 16. In: Block JH, Beale JM, editors. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th ed. Philadephia: Lippincott Williams & Wilkins. 2010. p. 519-557. 


ORAL PRESENTATIONS: 

Liu, S, Lo, S. N.  "Targeted Delivery of Low-Molecular-Weight Anticancer Prodrugs".  Presented at the 3rd International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems.  Chicago/Northbrook, U.S.A.  April 8, 2013.  

Liu S, Berlin KD, Madler, MM, Brown CW, Benbrook DM, Nelson EC. “Synthesis and structure-activity relationships of nitrogen heteroarotinoids.” Presented at the 217th American Chemical Society National Meeting, Anaheim, March 21-25, 1999 

Crider AM, Liu S, Tang C, Ho B, Ankersen M, Stidsen C E. “Non-peptide somatostatin agonist with selectivity for the subtype 4 receptor.” Presented at the 218th American Chemical Society National Meeting, New Orleans, August 22-26, 1999. 

Liu, S and Louie, M. "Novel thiochromane ring modified SHetA2 analogs inhibit growth of ER positive breast cancer cell MCF7". 111th Annual Meeting of the American Association of Colleges of Pharmacy, Seattle, Washington, July-10-14, 2010. American Journal of Pharmaceutical Education. 2010; 75(5) Article 96. p. 22.

American Chemical Association 
American Association of Colleges of Pharmacy 
American Association of Pharmaceutical Scientists 

2012 Best Lecturer of the Year Awards by College of Pharmacy Students  

2007 Best Lecturer and Professor of the Year Awards by College of Pharmacy Students

1998 Classified as an extraordinary ability immigrant by INS 
1987 Award for excellence in Bioactivity guided fractionation and characterization of plant constituents, College of Pharmacy, The University of Illinois at Chicago 

Employer Title From - To
Heilongjiang University of Chinese Medicine / College of Pharmacy Instructor 1983-1986
University of Illinois at Chicago Visiting Scientist 1986-1987
Heilongjiang University of Chinese Medicine / College of Pharmacy Assistant Professor 1988-1991
Albany Molecular Research Inc. Senior Research Scientist 1991-2005
Touro University – California / College of Pharmacy Assistant Professor 2006-now
     

Back to Top

Last Updated: 5/5/17