Faculty & Staff at TUC
Department: Biological & Pharmaceutical Sciences
Title: Associate Professor
Phone: (707) 638-5983
Fax: (707) 638-5255
Office: Administration & Faculty 2, Rm. 207
|Institution||Degree||Field of Study||Obtained|
|Shenyang Pharmaceutical University||B.S., M.S||Pharmacy||1982|
|The University of Louisiana at Monroe||Ph.D.||Medicinal Chemistry||1997|
|Oklahoma State University||Postdoc||Medicinal Chemistry||1999|
|The University of Texas at Austin||Postdoc||Medicinal Chemistry||2001|
PHRM 602: Pharmaceutical Sciences (Participating Faculty Member)
PHRM 610: Pharmaceutical Sciences (Participating Faculty Member)
PHRM 606: Pharmaceutical Sciences (Participating Faculty Member)
PHRM 614: Pharmaceutical Sciences (Participating Faculty Member)
Intramural Grants - Funded
Touro University Intramural Grant (2008) for Design, Synthesis and Pharmacological Evaluation of Polar SHetA2 analogs as Novel Anti-cancer Agents. ($ 20,000.00)
Touro University Intramural Research Award Program (IRAP) (2011) for Mechanism of Action of Novel Thiourea Anticancer agents. ($ 4,554.00)
US Patent: Tocopherols, Tocotrienols, Other Chroman and and Side Chain Derivatives and Uses Therof. Bob G. Sanders; Kimberly Kline; Laurence Hurley; Robb Gardner; Marla Menchaca; Weiping Yu; Puthucode N. Rammanan ; Shengquan Liu; Karen Israel
US Patent: 6,417,223 B1 (2002)
US Patent: 2002/0156024 A1, 2002
US Patent: 6,645,998, 2003
US Patent: 6,770,672 B1, 2004
US Patent: 2004/0235938 A1, 2004
US Patent: 73112232, 2007
US Patent: 20080119514, 2008
EP 1115398 EP1115398 and WO0016772
Shengquan Liu, Maggie C. Louie, Vanishree, Rajagopalan, Guangyan Zhou, Esmeralda Ponce, Tran Nguyen, and Linda Green. Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents. Bioorganic & Medicinal Chemistry Letter . Accepted.
Lin Y, Chen S, Yue P, Zou PW, Benbrook DM, Liu S, Le TC, Berlin KD, Khuri FR, Sun
S-Y. CHOP-Dependent upregulation of death receptor 5 is a major component of apoptotic
cell death induced by the flexible heteroarotinoid SHetA2 in human lung cancer cells.
Cancer Research. 2008; 68 (13): 5335-44.
Norman BH, Richardson TI, Dodge JA, Pfeifer LA, Durst GL, Wang Y, Durbin JD, Krishnan V, Dinn SR, Liu S, Reilly JE, Ryter KT. Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring. Bioorg Med Chem Lett. 2007; 17 (18): 5082-5
Liu S, Brown CW, Berlin KD, Dhar A, Guruswamy S, Brown D, Benbrook DM. Synthesis of flexible sulfur-containing heteroarotinoids that induce apotosis and reactive oxygen species with discrimination between malignant and benign cells. J Med Chem. 2004; 47, 999-1007.
Brown CW, Liu S, Klucik J, Berlin KD, Brennan PJ, Kaur D, Benbook DM. Novel heteroarotinoids as potential antagonists of mycobacterium bovis BCG. J Med Chem. 2004; 74, 1008-17.
Crider AM, Liu S, Li T, Mahajan S, Ankersen M, Stidsen C E. Somatostatin receptor subtype 4(sst4) ligands: synthesis and evaluation of indol-3-yl-and 2-pyridyl-thioureas. Lett Drug Des discov. 2004; 1, 84-7.
Liu S, Berlin KD, Simms-Kelly MD, Nelson EC, Benbrook D M. Optimization and synthesis of (E)-4-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-1-propenyl]benzoic acid-11-[14C]. J Label Compds RadioPharm. 1999: 42, 789-96.
Dhar A, Liu S, Berlin KD, Madler MM, Birckbichler PJ, Lu S, Ivey TT, Zacheis D, Brown DW, Klucik J, Nelson EC, Benbrook DM. Synthesis and structure-activity relationships and RAR-ligand interaction of nitrogen heteroarotinoids. J Med Chem. 1999; 42, 3602-14.
Liu S, Crider AM, Tang C, Ho B, Ankersen M, Stidsen CE. Novel non-peptide somatostatin agonists with sst4 selectivity. Curr Pharm Des. 1999; 5, 255-63
Zacheis D, Dhar A, Lu S, Madler MM, Klucik J, Brown CW, Liu S, Clement F, Subramanian S, Weerasekare GM, Berlin KD, Gold MA, Houch JRJr, Fountain KR, Benbrook DM. Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem. 1999, 42, 4434-45.
Liu S, Ho B, Tang C, Ankersen M, Stidsen C, Crider M. Non-peptide somatostatin agonists with sst4 selectivity: Synthesis and structure activity relationships of thioureas. J Med Chem 1998; 41, 5693-705.
Ankersen M, Crider M, Liu S, Ho B, Andersen HS, Stidsen C. Discovery of a novel non-peptide somatostatin agonist with sst4 selectivity. J Am Chem Soc. 1998; 120, 1360-73.
Benbrook DM, Subramanian S, Gale JB, Liu S, Bown CW, Boehm MF, Berlin KD. Synthesis and characterization of heteroarotinoids demonstrate structure-specificity relationships. J Med Chem. 1998; 41, 3753-7.
Medler MM, Klucik J, Soell PS, Brown CW, Liu S, Berlin KD, Benbrook DM, Birckbichler PJ, Nelson EC. Lithium hypochlorite-clorox as a novel oxidative mixture for methyl ketones and methyl carbinols. Org Prep Proced Int. 1998; 30, 230-4.
Liu S, Pezzuto JM, Kinghorn AD. Additional biologically active constituents of the chinese tallow tree. J Nat Prod. 1988; 51, 619-21.
Liu S. Central nervous system depressants. Chapter 12. In: Block JH, Beale JM, editors. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th ed. Philadephia: Lippincott Williams & Wilkins. 2010. p. 443-470.
Liu S. Adrenergic agents. Chapter 16. In: Block JH, Beale JM, editors. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th ed. Philadephia: Lippincott Williams & Wilkins. 2010. p. 519-557.
Liu, S, Lo, S. N. "Targeted Delivery of Low-Molecular-Weight Anticancer Prodrugs". Presented at the 3rd International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems. Chicago/Northbrook, U.S.A. April 8, 2013.
Liu S, Berlin KD, Madler, MM, Brown CW, Benbrook DM, Nelson EC. “Synthesis and structure-activity
relationships of nitrogen heteroarotinoids.” Presented at the 217th American Chemical
Society National Meeting, Anaheim, March 21-25, 1999
Crider AM, Liu S, Tang C, Ho B, Ankersen M, Stidsen C E. “Non-peptide somatostatin agonist with selectivity for the subtype 4 receptor.” Presented at the 218th American Chemical Society National Meeting, New Orleans, August 22-26, 1999.
Liu, S and Louie, M. "Novel thiochromane ring modified SHetA2 analogs inhibit growth of ER positive breast cancer cell MCF7". 111th Annual Meeting of the American Association of Colleges of Pharmacy, Seattle, Washington, July-10-14, 2010. American Journal of Pharmaceutical Education. 2010; 75(5) Article 96. p. 22.
American Chemical Association
American Association of Colleges of Pharmacy
American Association of Pharmaceutical Scientists
2012 Best Lecturer of the Year Awards by College of Pharmacy Students
2007 Best Lecturer and Professor of the Year Awards by College of Pharmacy Students
1998 Classified as an extraordinary ability immigrant by INS
1987 Award for excellence in Bioactivity guided fractionation and characterization of plant constituents, College of Pharmacy, The University of Illinois at Chicago
|Employer||Title||From - To|
|Heilongjiang University of Chinese Medicine / College of Pharmacy||Instructor||1983-1986|
|University of Illinois at Chicago||Visiting Scientist||1986-1987|
|Heilongjiang University of Chinese Medicine / College of Pharmacy||Assistant Professor||1988-1991|
|Albany Molecular Research Inc.||Senior Research Scientist||1991-2005|
|Touro University – California / College of Pharmacy||Assistant Professor||2006-now|
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