Faculty & Staff at TUC

Athena W. Lin

Athena W. Lin

College: COM

Department: Basic Sciences, Global Health, MSMHS, Research

Title: Associate Professor & Vice Director of Global Health Program

Phone: (707) 638-5239

Fax: (707) 638-5255

E-Mail: athena.lin@tu.edu

Office: Administration & Faculty 1, Rm. 226

Dr. Athena W. Lin is an Associate Professor and Vice Director of the Global Health Program (GHP) at Touro University California College of Osteopathic Medicine (TUCOM). She received a Bachelor degree in Pharmacy from China Medical University in Taiwan, and a Ph.D. from the University of Massachusetts in Amherst, MA. She further received a post-doctoral training from the Cold Spring Harbor Laboratory in Cold Spring Harbor, NY, where she became one of the pioneer researchers who uncovered oncogene-induced senescence. Dr. Lin subsequently furthered her senescence research in cancers as a Principal Investigator and Assistant Professor in the Department of Pharmacology and Cancer Therapeutics at Roswell Park Cancer Institute, Buffalo, NY. Dr. Athena Lin joined Touro University College of Osteopathic Medicine in 2007. As a faculty member in the Basic Science Department, she teaches pharmacology and acts as a Coordinator for the Fundamentals of Osteopathic Medicine course. As an active member of the Student Promotion Committee, she is responsible for monitoring the academic performance of the preclinical years. As the Vice Director of the TUCOM GHP, she works closely with the Program Director to manage the GHP to ensure the overall success. In addition to her laboratory research in the areas of biology of cancer and cellular senescence, Dr. Lin is also actively involved in global health research and medical education outcome assessment. Dr. Lin is passionate about providing excellent support to student learning and development in medical school.

Institution Degree Field of Study Obtained
China Medical University, Taiwan B.S. Pharmceutical Sciences 1985
University of Massachusetts, Amherst, MA Ph.D.   1995
Cold Spring Harbor Laboratory, New York Postdoctoral Fellow   1995-2001

 

Pharmacology
Integrated Systems
Global Health Program        

The biology of cellular senescence, aging and cancer.

The Greater Buffalo Community Foundation Research Award (PI) 2003
RPCI Alliance Foundation Research Award (PI) 2003
American Cancer Society Institutional Research Grant Award (PI) 2003
Ralph C. Wilson Medical Research Award (PI) 2005 
Ralph C. Wilson Medical Research Award (PI) 2006 
TUC Intramural Research Grant Award (Co-PI) 2008

TUC Intramural Research Grant Award (PI) 2011

TUC Intramural Research Grant Award (PI) 2013

Peer-Reviewed Publications in Journals 

1. Lin AW, Snoeyenbos G, and Goldsby RA. Salmonella enteritidis-specific monoclonal antibodies. 1992 Avian Diseases 36: 455-458. 

2. Lin AW, Usera MA, Barrett TJ, and Goldsby RA. Application of random amplified polymorphic DNA analysis to differentiate strains of Salmonella enteritidis. 1996 J. Clinical Microbiology 34: 870-876. 

3. Serrano M, Lin AW, McCurrach ME, Beach D, and Lowe SW. Oncogenic ras provokes premature senescence associated with accumulation of p53 and p16ink4a. 1997 Cell 88: 593-602. 

4. Lin AW, Barradas M, Stone J, van Aelst L , Serrano M, and Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. 1998 Genes & Development 12(19): 3008-3019. 

5. Lucier MR, Thompson RE, Waire J, Lin AW, Osborne BA, Goldsby RA. Multiple sites of V diversification in cattle. 1998 J. Immunology 15:161(10): 5438-5444. 

6. Lowe SW and Lin AW. Apoptosis in cancer. 2000 Carcinogenesis 21(3): 485-495. 

7. Lin AW and Lowe SW. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. 2001 Proceedings of the National Academy of Sciences 98(9): 5025-5030. 

8. Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach M, Hannon GJ, and Lowe SW. Oncogenic ras converts tumor suppressor p53 to activate a senescence program. 2002 Molecular and Cellular Biology 22(10): 3497-508. 

9. Kondo S, Lu Y, Debbad M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Low SW, Mak TW, Thurkral SK. Characterization of cells and gene-targetd mice deficient for the p53-binding kinase HIPK1. 2003 Proceedings of the National Academy of Sciences 100:5431-36. 

10. Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn S, Spector DL, Hannon GJ, and Lowe SW. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. 2003 Cell 113:703-16. 

11. Bihani T, Mason DX, Jackson TJ , Chen CS , Bottner B, and Lin AW. Differential Oncogenic ras signaling and senescence in tumor Cells. 2004 Cell Cycle 3(9): 1201-1207. 

12. Mason DX, Jackson TJ, and Lin AW. Molecular Signature of ras-induced senescence. 2004 Oncogene 23: 9238-9246. 

13. Weebadda WKC, Jackson TJ, and Lin AW. Expression of distinct p16 variants in senescent human fibroblasts independent of protein phosphorylation. 2005 J. Cellular Biochemistry 94 (6): 1135-1147. 

14. Zu, K, Bihani T, Lin, A, Park, Y-M, Mori, K, and Ip, C. Enhanced Selenium Effect on Growth Arrest by BiP/GRP78 Knockdown in p53-null Human Prostate Cancer Cells. 2006. Oncogene 25(4):5546-554. 

15. Mason DX, Keppler D, Zhang J, Jackson TJ, Seger YR, Matsui S, Fleurette Abreo, Cowell J, Hannon GJ, Lowe SW, and Lin AW. Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. 2006. Carcinogenesis 27(2) 350-359. 

16. Bihani T, Chicas A, Lo CP, and Lin AW. Dissecting a senescence-like program in tumor cells activated by Ras signaling. 2007 JBC 282(4):2666-75 (November 29, 2006 online publication) 

17. Li, Y, Lin, AW, Zhang X, Wang, Y, Wang, X, and Goodrich DW. Cancer cells and normal cells differ in their requirements for Thoc1. 2007 Cancer Research 67(14):6657-6664 

18. Li YP, Lin AW, Zhang XJ, Wang YQ, Wang XL, Goodrich DW. Thoc1 as a potential molecular target for cancer therapy.2007 Medicina-Buenos Aires, 67: 13-19 

19. Gregorie CJ, Wiesen JL, Magner WJ, Lin AW, Tomasi TB. Restoration of immune response gene induction in trophoblast tumor cells associated with cellular senescence. 2009 Journal of Reproductive Immunology (June 2009 epub ahead doi:10.1016/j.jri.2009.02.009) 

20. Sheu JJ, Choi JH, Guan B, Lin AW, Lee C, Tsai F, Wang T, Shih I-M. Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability through defective p53 checkpoint.  JBC 2010 Dec 3;285(49):38260-9.

21. Keppler D., Zhang J., Bihani T., Lin AW. Novel Expression of CST1 as Candidate Senescence Marker. 2011 J Gerontolology. 2011 Jul;66(7):723-31.

Published Book Chapter

  1. 1.      Diep Crystal M., Kaur G., Keppler D., and Lin AW. Retroviral Expression of Human Cystatin Genes in HeLa Cells. 2014 Cervical Cancer: Methods in Molecular Biology, Vol. 1249. Chapter 9.  p. 121-131. ISBN 978-1-4939-2012-9.

 

Published Book (Editor)

Editors: Keppler Daniel, Lin Athena W. Cervical Cancer: Methods and Protocols, Methods in Molecular Biology. Vol. 1249.  ISBN 978-1-4939-2012-9.2015

 

 

Teacher of the Year in Basic Sciences (2011)

Teacher of the Year in basic Sciences (2013)

Graduation Hooder of the Class 2013
Graduation Hooder of the Class 2015

 

Employer Title From - To
Sintong Pharmaceutical Co., Taoyuan,  Taiwan (Currently, Taiwan Biotech Co., Ltd.) R&D Scientist 1986-1988
Department of Pediatrics, Chang Gung Hospital, Taipei, Taiwan Research Associate 1988-1989
Roswell Park Cancer Institute, Pharmacology & Therapeutics, NY Assistant Member 9/2001-1/2007
SUNY-RPCI Graduate Division, Mol. Pharm & Cancer Therap. Buffalo, NY Assistant Professor 9/2001-1/2007

 

Last Updated: 9/28/16