Faculty & Staff at TUC

Gloria J. Klapstein

College: COM

Department: Basic Sciences

Title: Associate Professor

Phone: Office (707) 638-5271, Lab (707) 638-5407

Fax: (707) 638-5255

E-Mail: gloria.klapstein@tu.edu

Office: Administration and Faculty 1, Rm. 124

Institution Degree Field of Study Obtained
University of Alberta B.Sc. Biology/Chemistry 1986
University of Alberta Ph.D. Pharmacology 1995
UCLA Postdoc Neurophysiology 1995-1998
UCLA Postdoc Neurophysiology/Neurodegenerative Disorders 1998-2004
I teach lectures in Physiology and Pharmacology in both the School of Medicine and the School of Health Sciences.
My lecture topics include:

Introduction to Neurology
- Neuroembryology
- Synaptic transmission
- Neuronal injury and repair
- Auditory physiology
- Special senses (taste and smell)
- Sleep physiology

Basic Science Foundations
- Membrane properties
- Membrane potential
- Action potentials
- Ligands and receptors

Clinical Medicine
- Renal Physiology
- GI physiology

Pharmacology
- Antidepressants
- Antipsychotics
- Movement disorders and Alzheimer's disease
- Renal pharmacology
•Colmers, W.F., Klapstein, G.J., Fournier, A., St-Pierre, S. and Treherne, K.A. (1991) Presynaptic inhibition by neuropeptide Y (NPY) in rat hippocampal slice in vitro is mediated by a Y2 receptor. Br. J. Pharmacol. 102: 41-44.

Klapstein, G.J. and Colmers, W.F. (1992) 4-Aminopyridine and low Ca++ differentiate presynaptic inhibition mediated by Neuropeptide Y, Baclofen and 2-Chloroadenosine in rat hippocampal CA1 in vitro. Br. J. Pharmacology 105: 470-474.

Klapstein, G.J. and Colmers, W.F. (1993) On the sites of presynaptic inhibition by Neuropeptide Y (NPY) in rat hippocampus in vitro. Hippocampus 3: 103-112.

Klapstein, G.J. and Colmers, W.F. (1997) Neuropeptide Y inhibits epileptiform activity in the rat hippocampus in vitro. J. Neurophysiol. 78: 1651-1661. (pdf)

Klapstein, G.J., Vietla, S., Lieberman, D.N., Gray, P.A., Airaksinen, M.S., Thoenen, H., Meyer, M., and Mody, I. (1998) Calbindin-D28k fails to protect hippocampal neurons against ischemia in spite of its cytoplasmic calcium buffering properties: evidence from calbindin-D28k knockout mice. Neuroscience 85: 361-373. (pdf)

Klapstein, G.J., Meldrum, B.S., and Mody, I. (1999) Decreased sensitivity to Group III mGluR agonists in the lateral perforant path following kindling. Neuropharmacol. 38: 927-933. (pdf)

•Levine, M.S., Klapstein, G.J., Koppel, A., Gruen, E., Cepeda, C., Vargas, M.E., Jokel, E.S., Carpenter, E.M., Zanjani, H., Hurst, R.S., Efstratiadis, A., Zeitlin, S., and Chesselet, M.-F. (1999) Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington’s disease. J. Neuroscience Res. 58: 515-532. (pdf)

Klapstein, G.J., Fisher, R.S., Zanjani, H., Cepeda, C., Jokel, E.S., Chesselet, M.-F., and Levine, M.S. (2001) Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington’s disease transgenic mice. J. Neurophysiology 86: 2667-2677. (pdf)

•Laforet, G.A., Sapp, E., Chase, K., McIntyre, C., Boyce, F.M., Campbell, M. Cadigan, B.A., Warzecki, L., Tagle, D.A., Reddy, H., Cepeda, C., Calvert, C.R., Jokel, E.S., Klapstein, G.J., Ariano, M.A., Levine, M.S., DiFiglia, M., and Aronin, N. (2001) Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington’s disease. J. Neuroscience 21: 9112-9123. (pdf)

•Cepeda C., Hurst, R.S., Flores-Hernandez, J., Hernandez-Echeagaray, E., Klapstein, G.J., Boylan, M.K., Calvert, C.R., Jocoy, E.L., Nguyen, O.K., Andre, V.M., Vinters, H.V., Ariano, M.A., Levine, M.S., and Mathern, G.W. (2003) Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia. J. Neurosci. Res. 72: 472-486. (pdf)

•Goldberg, M.S., Fleming, S.M., Palacino, J.J., Cepeda, C., Lam, H.A., Bhatnagar, A., Meloni, E.G., Wu, N., Ackerson, L.C., Klapstein, G.J., Gajendiran, M., Roth, B.L., Chesselet, M.-F., Maidment, N.T., Levine, M.S., and Shen, J. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278: 43628-43635. (pdf)

Klapstein, G.J. and Levine, M.S. (2005) Age-dependent biphasic changes in ischemic sensitivity in the striatum of Huntington’s Disease R6/2 transgenic mice. J Neurophysiol. 93: 758-765. (pdf)

•Ariano M.A., Cepeda C., Calvert C.R., Flores-Hernandez J., Hernandez-Echeagaray E., Klapstein G.J., Chandler S.H., Aronin N., Difiglia M., Levine M.S. (2005) Striatal Potassium Channel Dysfunction in Huntington's Disease Transgenic Mice. J. Neurophysiol. 93: 2565-2574. (pdf)

•Cepeda C., Andre V.M., Flores-Hernandez J., Nguyen O.K., Wu N., Klapstein G.J., Nguyen S., Koh S., Vinters H.V., Levine M.S., Mathern G.W. (2005) Pediatric cortical dysplasia: correlations between neuroimaging, electrophysiology and location of cytomegalic neurons and balloon cells and glutamate/GABA synaptic circuits. Dev Neurosci. 27:59-76. (pdf)


BOOK CHAPTERS
•Colmers, W.F., McQuiston, A.R., Kombian, S.B., and Klapstein, G.J. Presynaptic inhibition mediated by Neuropeptide Y in the mammalian CNS: possible physiological implications, in: Presynaptic neurotransmitter receptors in mammalian CNS, D. Lovinger and T.V. Dunwiddie (eds.), Birkhauser, Boston. pp. 87-103 (1993).

ABSTRACTS
•Colmers, W.F. and Klapstein, G.J. (1989) Neuropeptide Y does not inhibit the perforant path - dentate granule cell synapse in rat hippocampal slice. Soc. Neurosci. Abst. 15: 218.

Klapstein, G.J., Treherne, K.A. and Colmers, W.F. (1990) Neuropeptide Y presynaptic effects in hippocampal slice in vitro are Y2 receptor-mediated but not via inhibition of adenylate cyclase. Ann. N.Y. Acad. Sci. 611: 457 - 458.

•Colmers, W.F. and Klapstein, G.J. (1990) Presynaptic inhibition by neuropeptide Y (NPY) and adenosine in rat hippocampus is by a different mechanism than baclofen. Soc. Neurosci. Abst. 16: 1022.

Klapstein, G.J. and Colmers, W.F. (1991) NPY inhibits feedforward IPSP's in hippocampus by reducing excitatory input to interneurons. Soc. Neurosci. Abst. 17: 975.

Klapstein, G.J. and Colmers, W.F. (1993) Neuropeptide Y inhibits epileptiform activity in rat hippocampus in vitro. NPY Cambridge 1993 Abstr. A4

Klapstein, G.J. and Colmers, W.F. (1993) Epileptiform activity in rat hippocampal slice is inhibited by neuropeptide Y. Soc. Neurosci. Abst. 19: 1869.

Klapstein, G.J., Wechsler, S., and Colmers, W.F. (1994) Does muscarine activate K+ channels at presynaptic terminals in hippocampal area CA1? Soc. Neurosci. Abst. 20: 1120.

Klapstein, G.J. and Colmers, W.F. (1995) Rhythmic excitatory synaptic events in CA3 interneurons. Soc. Neurosci. Abst. 21: 983.

Klapstein, G.J., Gray, P., Mody, I, Airaksinen, M.S., Meyer, M., and Thoenen, H. (1996) Enhanced recovery from oxygen/glucose deprivation of hippocampal CA1 EPSPs in calbindin knockout mice. Soc. Neurosci. Abst. 22: 1204.

Colmers, W.F., Pronchuk, N., Torok-Both, C., McQuiston, A.R., Klapstein, G.J., Ho, M., Aronyk, K., McKean, J., Sinclair, D.B., Javidan, M., and Beck-Sickinger, A.G. (1997) Neuropeptide Y inhibits synaptic excitation in epileptic human brain. Soc. Neurosci. Abstr. 23: 818.

Klapstein, G.J., Meldrum, B.S., and Mody, I. (1997) Decreased inhibition of glutamate release through Group III metabotropic glutamate receptors in the rat dentate gyrus following kindling. Soc. Neurosci. Abst. 23: 2421.

Klapstein, G.J., Meyer, M., and Mody, I. (1998) Calbindin-D28k (CB) knockout mice show decreased ischemic cell death in vivo: evidence against a neuroprotective role of CB. Soc. Neurosci. Abstr. 24: 1450.

•Colmers, W.F., Klapstein, G.J., McQuiston, A.R., Ho, M.W.Y. (1999) Sites and Mechanisms of NPY Anticonvulsant Actions in Vitro. Ital. J. Neurol. Sci. 20:197.

Klapstein, G.J., Koppel, A., Zeitlin, S., Dragatsis, I., and Levine, M.S. (1999) Striatal medium-sized spiny neurons (MSSNs) show depolarized resting potentials (RMPs) in transgenic mouse models of Huntington’s Disease (HD). Soc Neurosci. Abstr. 25: 46.

•Cepeda, C., Hurst, RS., Flores-Hernandez, J., Klapstein, G.J., Mathern, G.W., and Levine, M.S. (1999) Morphological and electrophysiological abnormalities in cortical neurons revealed by infrared videomicroscopy and whole-cell patch clamp recordings in pediatric cortical dysplasia. Soc. Neurosci. Abstr. 25: 602.

Klapstein, G.J., Chesselet, M.-F., Zanjani, H., Fisher, R.S., and Levine, M.S. (2000) Electrophysiological and morphological changes in striatal neurons in asymptomatic and symptomatic R6/2 Huntington's disease (HD) transgenic mice. Soc Neurosci. Abstr. 382.8.

•Flores-Hernandez, J., Cepeda, C., Mathern, G.W., Klapstein, G.J., Calvert, C.R., Jokel, E.S., Ariano, M.A., Buchwald, N.A., and Levine, M.S. (2000) Glutamatergic and GABAergic activity in slices and acutely dissociated cells from dysplastic developing human cortex. Soc. Neurosci. Abstr. 389.1.

•Ariano, M.A., Cepeda, C., Calvert, C.R., Klapstein, G.J., Koppel, A.H., Hernandez-Echeagaray, E., Flores-Hernandez, J.S., and Levine, M.S. (2000) Alterations in K+ channels in Huntington’s disease transgenic mice. Soc. Neurosci. Abstr. 382.9.

Klapstein, G.J., Flores-Hernandez, J., Cepeda, C., Calvert, C.R., Mathern, G.W and Levine, M.S. (2000) Spontaneous synaptic activity in slices from dysplastic developing human cortex. Amer. Epilepsy Soc. Abstr. 3.065.

Klapstein, G.J. and Levine, M.S. (2001) Ischemic tolerance in the R6/2 mouse model of Huntington’s Disease (HD). Soc. Neurosci. Abstr. 863.9.

•Goldberg, M.S., Fleming, S.M., Palacino, J.J., Cepeda, C., Lam, H.A., Meloni E.G.,Wu N., Ackerson, L.C., Klapstein, G.J., Gajendiran, M., Chesselet, M.-F., Maidment, N.T., Levine, M.S., Shen, J. (2003) Parkin knockout mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. Soc. Neurosci. Abstr. 408.2.
1982
Alberta Heritage Foundation Award of Excellence

1991-1992
Savoy Foundation Graduate Studentship

1992
German Consulate Book Prize for Language Development

1992 -1995
Henri M. Toupin Medical Foundation Graduate Studentship

1993 - 1995
Alberta Heritage Foundation for Medical Research Graduate Studentship

1993
Mary Louise Imrie Graduate Award

1995-1998
Alberta Heritage Foundation for Medical Research Postdoctoral Fellowship

2000-2002
Huntington’s Disease Society of America Postdoctoral Fellowship
Employer Title From - To
Touro University - California Assistant Professor 2004 - Present
Last Updated: 10/21/15