Faculty & Staff at TUC

Dr Kevin  Ita

Kevin Ita

College: COP

Department: Biological & Pharmaceutical Sciences

Title: Associate Professor

Phone: (707) 638-5994

Fax: (707) 638-5266

E-Mail: kevin.ita@tu.edu

Office: Administration & Faculty 2, Rm. 210

Institution Degree Field of Study Obtained
Lviv Medical University, Ukraine MSc Pharmacy 1986
NorthWest University, South Africa Ph.D. Pharmaceutics 2004

Fall Semester• 
PHRM 602: Pharmaceutical Sciences (Participating Faculty Member)
PHRM 610: Pharmaceutical Sciences (Participating Faculty Member) 

Spring Semester• 
PHRM 606: Pharmaceutical Sciences (Participating Faculty Member) 
PHRM 614: Pharmaceutical Sciences (Participating Faculty Member) 

Currently, there is tremendous interest in the use of physical techniques for transdermal drug delivery. The goal of our research is to investigate various technologies for transdermal drug delivery enhancement. Our experience with various therapeutic agents indicates that passive diffusion through the stratum corneum is difficult especially to hydrophilic and charged compounds. Our future approach is to use mild electric current (iontophoresis) , ultrasound (sonophoresis) and microneedles to increase transcutaneous flux. Iontophoresis uses low-level electric current to drive ionized drug molecules into or through the skin. Typically, the current may be about 0.2 mA/sq cm and is almost imperceptible at this level. By using an electrode of the same polarity as the charge on the drug, the drug is driven into the skin by electrostatic repulsion. 
Our second approach is the use of ultrasound (sonophoresis) for flux enhancement. Ultrasound has been shown to enhance transdermal permeability of various drugs. It has been suggested that the enhancement may be due to local heating and/or cavitation i.e. formation and oscillation of small gaseous inclusion. The third approach is through the use of microneedles.These are micron-sized needles that are long enough to porate the stratum corneum but short enough to avoid nerve endings located in the dermis. Thus it is a painelss and minimally invasive technique. Our laboratory will focus on the development of clinically useful formulations by using these techniques. 

Back to Top

Kevin Ita UICC Fellow (2000) 

 

1. J.D. Ladnaya, Kevin Ita (1986) Photocolorimetric determination of soluthisone in Dosage forms and Serum. In: Optimisation of Drug Supply and increasing the effectiveness of Pharmaceutical Sciences, Ukrainian Academy of sciences pp. 133-134. 

2. J.D.Ladnaya, Kevin Ita (1987) Formulation of Soluthisone granules for Children.In: Improving the Process of Drug Research and Production, Russian Institute for Pharmaceutical Research pp. 223-224. 

3. K.B.Ita, E.E.Essien, O.E.Offiong (2000) Determination of 2-acetylpyridine (4-phenylthiosemicarbazone) and its metal Complexes-Potential Antineoplastic Agents, West African Journal of Pharmacy, 14, pp.58-60 

4. K.B.Ita, J. Du Plessis, J. Hadgraft, J. Du Preez (2003) Skin delivery of acyclovir from elastic liposomes. In: Emerging Health Care Priorities: Towards optimal Drug Therapy. Proceedings of the 24th Congress of the South African Academy of Pharmaceutical Sciences 

5. K. B. Ita, J. Du Preez, M. E. Lane, J. Hadgraft, J. Du Plessis (2007) Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid concentration and surfactants. Journal of Pharmacy and Pharmacology, 59, 1215-122 

6. K.B.Ita, A.K.Banga (2009) In vitro transdermal iontophoretic delivery of penbutolol sulfate. Drug Delivery, 16:11-14 

7. K. Ita, N. Hatsakorzian, and V. Tolstikov (2013) Microneedle-Mediated Delivery of Atenolol and Bisoprolol Hemifumarate J. Nanopharmaceutics Drug Delivery 1, 38-44

8. M. Kaur, K. B. Ita, I. E. Popova, S. J. Parikh, D. A. Bair (2014) Microneedle-assisted delivery of verapamil hydrochloride and amlodipine besylate. Eur J Pharm Biopharm. 86, 284-291 

9. K.B.Ita (2014) Transdermal Drug Delivery: Progress and Challenges J. Drug Delivery Sci Tech

24(3) 245-250.

10. Nguyen K.T., Ita K.B., Parikh S.J., Popova I. E., Bair D. A (2014) Transdermal Delivery of Captopril and Metoprolol Tartrate with Microneedles. Drug Delivery Letters, 4,236-243.

11. Kim K.S., Ita  K., Simon L (2015) Modelling of Dissolving Microneedles for Transdermal Drug Delivery. European Journal of Pharmaceutical Sciences, 68, 137-143.

12. Ita K.B (2015) Transdermal drug delivery with microneedles-strategies and outcomes. Journal of Drug Delivery Science and Technology, 29, 16-23.

13. Ita, K.B (2015) Transdermal Delivery of Drugs with Microneedles— Potential and Challenges.  Pharmaceutics, 29;7(3):90-105

14. Ita, K.B. (2015) Chemical penetration enhancers for transdermal drug delivery-success and challenges. Current Drug Delivery,  12(6):645-51.

15. Ita, K.B., Popova, I.E.(2015) Influence of sonophoresis and chemical penetration enhancers on percutaneous transport of penbutolol sulfate. Pharmaceutical Development and Technology, Accepted for publication.

16. Ita, K.B (2015) Transdermal iontophoretic drug delivery: advances and challenges. Journal of Drug Targeting, Accepted for publication.

17. Hoang, M.T., Ita, K.B., Bair, D.A. (2015) Solid Microneedles for transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride, Pharmaceutics7(4):379-96

18. Simon L,  Ospina J, Ita K(2015) Prediction of In-Vivo Iontophoretic Drug Release Data from In-Vitro Experiments - Insights from Modeling Mathematical Biosciences 270(Pt A):106-14

19. Ita K. (2015) Recent progress in transdermal sonophoresis.  Pharmaceutical Development and Technology. Accepted for publication.

20. Ita, K.B. (2015) Transdermal delivery of heparin : physical enhancement techniques. International Journal of Pharmaceutics. 496(2):240-9 

21. Ita K (2016)Progress in the use of microemulsions for transdermal and dermal drug delivery. Pharmaceutical Development and Technology. Accepted for publication.

22. Ita, K.B. (2016)Prodrugs for transdermal drug delivery- trends and challenges. Journal of Drug Targeting. Accepted for publication.

23. Ita K.B. (2016) Perspectives on transdermal electroporation. Pharmaceutics. Accepted for publication

24. Ita K.B. (2016) Current status of ethosomes and elastic liposomes in dermal and transdermal drug        delivery.  Current Pharmaceutical Design. Accepted for publication.

25. Ita K.B. (2016) Reflections on the insertion and fracture forces of microneedles. Current Drug Delivery. Accepted for publication.

26. Ita K.B. (2016) Insights into the percutaneous penetration of antidiabetic agents. Journal of Drug Targeting. 25:102-111

27. Ita K.B. (2016) Transdermal delivery of vaccines- recent progress and critical issues. Biomedicine & Pharmacotherapy83:1080-1088

28. Ita K.B. (2016) Percutaneous penetration of anticancer agents: past, present and future. Biomedicine and Pharmacotherapy84:1428-1439

29. Ita K.B. (2016) Recent trends in the transdermal delivery of therapeutic agents used for the management of neurodegenerative diseases. Journal of Drug Targeting25:406-419

30. Nguyen J., Ita K.B., Popova I.E., Morra M. (2016) The influence of solid microneedles on the transdermal delivery of selected antiepileptic drugs. Pharmaceutics. ;8(4). pii: E33.

31. Ita K.B. (2017) Dermal/transdermal delivery of small interfering RNA and antisense oligonucleotides- advances and hurdles. Biomedicine and Pharmacotherapy87: 311-320

32. Ita K.B. (2017) Percutaneous transport of psychotropic agents Journal of Drug Delivery Science and Technology, 39: 247-259

 

 Poster Presentations 


Nguyen, K.T., Ita, K.B (2014) Influence of microneedles on transdermal delivery of metoprolol tartrate. Annual Meeting of the American Association of Pharmaceutical Scientists, San Diego, California, Abstract M1220.

K.B.Ita (2008) Sonophoretic transport of penbutolol sulfate: In vitro studies Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, Atlanta, Georgia. Abstract no.2237.p 96 


K.B.Ita,A.K. Banga (2008) In vitro transdermal iontophoretic delivery of penbutolol sulfate. Annual Meeting of the Controlled Release Society, New York City. Abstract no. 371 p. 71 

Fellow, International Union Against Cancer, Tenerife, Spain 
Member, American Association of Colleges of Pharmacy 
Member, American Association of Pharmaceutical Scientists 
Member, Controlled Release Society 

EmployerTitleFrom - ToUniversity of Calabar Teaching HospitalPharmacist-Intern1986-1987General Hospital, Tudun Wada, Kaduna, NigeriaPharmacist1987-1988Flobett Pharmacy, Lagos, NigeriaPharmacist1989-1990Vicon Pharmacy, Calabar, NigeriaPharmacist1991-1993Ansa Eso Pharmacy, Calabar, NigeriaPharmacist1993-1995Lanita Pharmacy, Calabar, NigeriaPharmacist1995-1996University of La Laguna, Tenerife, SpainUICC Fellow2000University of Uyo/Dept. of PharmaceuticsLecturer1997-2002Touro University – California / College of PharmacyAssistant Professor2006-now

Last Updated: 5/5/17