Faculty & Staff at TUC

Evan Hermel

Evan Hermel

College: COM

Department: Basic Sciences, MSMHS, Preclinical Education, Research

Title: Professor

Phone: (707) 638-5241

Fax: (707) 638-5255

E-Mail: evan.hermel@tu.edu

Office: Administration & Faculty 1, Rm. 225

Institution Degree Field of Study Obtained
University of Texas Southwestern Medical Center, Dallas, TX PhD Immunology 1992
C.W. Post College of Long Island University, Greenvale, NY M.S. Medical Biology/Immunology 1983
Hofstra University, Hempstead, NY B.A. Biology 1978

Back to Top

Teaching experience:
Touro University College of Osteopathic Medicine

Dr Hermel lectures in Basic and Clinical Immunology and Medical Microbiology in the following COM courses:

IS-Fundamentals of Osteopathic Medicine (MED 600)

IS-Central Nervous System/Musculoskeletal (MED 604)

IS-Cardiovascular/Respiratory/Renal (MED 622)

IS-GERD (MED 642)

Infection and Immunity  (HS607)   (MSMHS program)

                         

I have recently shifted my research focus to the RWDD4 protein, which has an unknown function.  My lab is examining the protein and its predicted interactions with several other proteins.  Findings may further our knowledge of processes involved in programmed cell dear, neuronal degeneration, and/or oncogenic processes.

Current and past student researchers in the lab:
Daisy Chan, MS; TUCOM Class of 2020
Angadpreet Sidhu, MS; TUCOM Class of 2019
Amrita Mahesh, MS; TUCOM Class of 2018
Emily Simon, MS; TUCOM Class of 2017
Trista Fuchs, MPH; TUCOM Class of 2017
Laura Marshal, MPH; TUCOM Class of 2017
Jeff Chiu, MS TUCOM Class of 2016
Mohammad Obaidullah, MS; TUCOM Class of 2017


Grants and Fellowships

Completed:

2011  PI, Intramural Research Project Proposal: Role of CASPASE-12 in African-Americans with systemic lupus erythematosus (Direct costs $10,000).  G. Brinkley and L.A. Russell, co-PIs. Touro University-CA. 

2011    PI, Intramural Research Project Proposal: Role of Caspase-12 in African-Americans with         systemic lupus erythematosus (Direct costs $10,000).  G. Brinkley and L.A. Russell, co-PIs. Touro University-CA.  In progress through 6/30/12

2011    Co-PI Intramural Pilot Project Grant:  Examination of altered monocarboxylate transporter expression in HD transgenic mice.  (Direct costs $3,000).  Gloria Klapstein, PI. Touro University-CA.

2010    Co-PI COHS Pilot Project Grant: Role of Caspase-12 genes in African-Americans with rheumatoid arthritis.  Kevin Klapstein, Co-PI (Direct costs $3000).  Touro University-CA, Vallejo, CA

2010  Co-PI COHS Pilot Project Grant: Role of Caspase-12 genes in African-Americans with rheumatoid arthritis.  Kevin Klapstein, Co-PI (Direct costs $3000).  Touro University-CA, Vallejo, CA

2009  Collaborator, R21 NS066469, Assay development for high affinity non-peptide HIV-1 gp41 inhibitors (Direct costs $100,000).  NIH-ADDT Miriam Gochin, Co-PI. Touro University-CA, Vallejo, CA.

2009    Collaborator, R21 NS066469,Assay development for high affinity non-peptide HIV-1 gp41 inhibitors (Direct costs $100,000).  NIH-ADDT Miriam Gochin, Co-PI. Touro University-CA, Vallejo, CA. 

 

E. Hermel.  Caspase-12 and lupus: the curious case of the dog that didn’t bark. 2016.  Inflammation & Cell Signaling.  e3:1383.

E. Hermel.  Caspase-12, rheumatoid arthritis, and the dog that didn’t bark. 2016.  Immunogenetics Online Access,1:1-3

T. Fuchs, J.A. Kelly, E. Simon, K. L. Sivils and E. Hermel.  The anti-inflammatory CASPASE-12 gene does not influence SLE phenotype in African-Americans.  2016.  Immunology Letters173: 21–25

L. Marshall, M. Obaidullah, T. Fuchs, N.S. Fineberg, G. Brinkley, T.R. Mikuls, S. L. Bridges Jr. and E. Hermel.  2014.  CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics 66:281-5

M. Yavari, K.D. Klapstein, W.C. Hartwig, R. Rao, and E. Hermel.    2012.  Identification of the functional caspase-12 allele in Indian subpopulations. Int. J. Immunogenetics. 39:389-93

E. Hermel and K.D. Klapstein.  2011. A possible mechanism for maintenance of the deleterious allele of human CASPASE-12Med. Hypotheses 77:803–806

G. Zhou, D. Wu, E. Balogh, E. Hermel and M. Gochin.  2010.  Design, synthesis and evaluation of indole compounds as novel inhibitors targeting gp41.  Bioorg. Med. Chem. Lett.20:1500-1503.

J.E. Young, L. Gouw, S. Propp, B.L. Sopher, J. Taylor, A. Lin, E. Hermel, A. Logvinova, S.F. Chen, S. Chen, D.E. Bredesen, R. Truant, L.J. Ptacek, A.R. La Spada, and L.M. Ellerby.  2007.  Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.  J. Biol. Chem.  282:30150-60.

E. Hermel, A.J. Hart, I. Gunduz, H. Acton, C. Kim, M. Wurth, S. Uddin, C. Smith, K. Fischer Lindahl and C.J. Aldrich.  2004.  Polymorphism and conservation of the genes encoding Qa1 molecules.   Immunogenetics.  56:639-49.

 J. Gafni, E. Hermel, J. Young, C.L. Wellington, R. Siman, M.R. Hayden and L.M. Ellerby.  2004.  Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.  J. Biol. Chem.  279:20211-20.

E. Hermel, J.Gafni, S.S. Propp, B.R. Leavitt, C.L. Wellington, J.E. Young, A.S. Hackam, A.V. Logvinova, A.L. Peel, S.F. Chen, V. Hook, R. Singaraja, S.Krajewski, P.C. Goldsmith, H.M. Ellerby, G.S. Salvesen, M.R. Hayden, D.E. Bredesen, and L.M. Ellerby. 2004.  Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington’s disease.  Cell Death Differentiation. 11:424-438.

R.V. Rao, A. Peel, A. Logvinova, G. del Rio, E. Hermel, T. Yokota, P.C. Goldsmith, L.M. Ellerby, H.M. Ellerby and D.E. Bredesen.  2002.  Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Letters 25777:1-7.

T. Chun, E. Hermel, H. R. Gaskins, and C.J. Aldrich.  2001.  CTL and cDNA sequence analyses of the MHC class Ib molecule Qa1 in nonobese diabetic (NOD) mice. Immunogenetics. 53:506-510.

R. Rao, E. Hermel, S. Castro-Obregon, A. Logvinova, G. Del Rio, L. M. Ellerby, P.C. Goldsmith, H.M. Ellerby and D.E. Bredesen.  2001.  Coupling endoplasmic reticulum stress to the cell death program: mechanism of caspase activation. J. Biol. Chem.  276:33869-74.

E. Hermel, C. Smith and C.J. Aldrich. 2000.  Allogeneic responses to the class Ib antigen Qa1: limited TcR Vα but not Vβ chain usage. Immunogenetics. 51:600-605.E. Hermel, A. Hart, R. Miller and C.J. Aldrich.  1999.  CTL and sequence analysis of MHC class IB antigens Qa1c (H2-T23r) and Qa1d (H2-T23f).  Immunogenetics. 49:712-717.

E. Hermel, M. Han, B. Hague, T. Kindt and J.J. Monaco.  1999.  Isolation and mapping of the DM genes of rabbit.  Implications for the evolution of the DM family. Immunogenetics.  49:295-302.

T. Chun, E. Hermel, C.J. Aldrich and H. R. Gaskins.  1999.  Porcine LMP7 proteasome subunit cDNA cloning and expression analysis.  Immunogenetics. 49:72-77.

E. Hermel, E. Grigorenko and C.J. Aldrich.  1997.  Increased class Ib antigen display on Tap-2 mutant cells by a mitochondrial function inhibitor.  Cell. Immunology. 178:10-15Kasai, M., K. Hirokawa, K.-I. Kajino, K. Ogasawara, M. Tatsumi, E. Hermel, J.J. Monaco and T. Mizuochi. 1996.  Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur J Immunol.  26:2101-2107.

E. Hermel, J. Yuan and J.J. Monaco.  1995.  Characterization of polymorphism within the H2-M MHC class II loci.  Immunogenetics.  42:136-142.

E. Hermel and J.J. Monaco.  1995.  RT1.DMa and RT1.DMb, the rat homologues of H2­‑DMa and H2-DMb.  Immunogenetics.  42:446-447.

E. Hermel, P. Robinson, J.-X. She and K. Fischer Lindahl.  1993.  Sequence divergence of β2-microglobulin alleles of wild Mus musculus and Mus spretus implies positive selection.  Immunogenetics.  38:106-116.

M. Attaya, S. Jameson, C.K. Martinez, E. Hermel, C. Aldrich, J. Forman, K. Fischer Lindahl, M.J. Bevan & J.J. Monaco.  1992 Ham-2 corrects the class I antigen processing defect in RMA-S cells.  Nature.  355:647-649.

C.J. Aldrich, R. Waltrip, E. Hermel, M. Attaya, K. Fischer Lindahl, J.J. Monaco and J. Forman.  1992.  Cytotoxic T lymphocyte recognition of Qa1b antigens on target cells lacking a functional Tap-2 transporter.  J. Immunol.  149:3773.-3777.

J.D. Davis, D.H Wilson, E. Hermel, G. Butcher, K. Fischer Lindahl & D.B. Wilson.  1991. Generation of T cells with lytic specificity for atypical antigens.  I.  A mitochondrial antigen in the rat.  J. Exp. Med.  173:823-832.

K. Fischer Lindahl, E. Hermel, B.E. Loveland and C.-R. Wang.  1991.  The maternally transmitted antigen: A model minor antigen.  Annu. Rev. Immunol.  9:351-372.

E. Hermel, E. Grigorenko and K. Fischer Lindahl.  1991.  Expression of medial class I histocompatibility antigens on RMA-S mutant cells.  Int. Immunol.  3:407-412.

C.-R. Wang, A. Livingstone, J. Howard, G. Butcher, E. Hermel and K. Fischer Lindahl.  1991.  Antigen presentation by neo-classical MHC class I gene products in murine rodents.  NATO ASI Series, Vol. H59: Molecular Evolution of the Major Histocompatibility Complex. J. Klein and D. Klein, eds.  Springer-Verlag, Berlin.  pp 441-462.

B. Loveland, C.-R. Wang, H. Yonekawa, E.Hermel, and K. Fischer Lindahl.  1990.  Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein.  Cell.  60:971-980.

J.D. Davis, D.H. Wilson, E. Hermel, G. Butcher, K. Fischer Lindahl and D.B. Wilson.  1990. A maternally-transmitted antigen system in the rat.  Transpl. Proc.  22:2547-2548.

K. Fischer Lindahl, E. Hermel, B.E. Loveland, S. Richards, C.-R. Wang, and H. Yonekawa. 1989.  Molecular definition of a mitochondrially encoded mouse minor histocompatibility antigen.  Cold Spring Harbor Symp. Quant. Biol.  56:563-569. 

Current TUCOM and University Committees:

8/13-date     Member, TU-CA Faculty Grievance Committee

5/13-date      Member, MSMHS Admissions Committee

4/12-date      Member TU-CA Research Committee

11/00-date    Member, TUCOM Admissions Committee

Extramural Service:

12/16               Ad hoc reviewer for Cancer Biomarkers

2013-date         Ad hoc reviewer for Medical Hypotheses

2015-date          Ad hoc reviewer for Evidence-Based Complementary and Alternative Medicine

2/2015-date       Seed Grant Reviewer, Touro UniversitySystem Intramural Grant Program

10/2014-date     Member, Science Advisory Board

2/2010-date        External Reviewer for AOA Research Grant and Abstract Proposals 

Awards and Honors

2008 Faculty Speaker, Class of 2008 Graduation

2008 Teacher of the Year Award, Class of 2008

2001 Faculty Service Award in Clinical Education

2000 Best Use of Case Studies Teaching Award

2000 Golden Lasso Faculty Unity Award

1992 Sigma Xi Graduate Student Research Forum Award

Positions:

7/2011-present Professor of Basic Science, Touro University College of Osteopathic Medicine, Vallejo, CA

7/2002-6/2011 Associate Professor of Basic Science, Touro University College of Osteopathic Medicine, Vallejo, CA

1/2000-12/2005 Visiting Scholar, Buck Institute for Age Research, Novato, CA

7/1999-6/2002 Assistant Professor of Basic Science, Touro University College of Osteopathic Medicine, Vallejo, CA

2/1997-5/1999 Assistant Scientist, Department of Microbiology and Immunology, Indiana University School of Medicine, Evansville Center, Evansville, IN

11/1992-2/1997 Postdoctoral Fellow, Department of Molecular Genetics, University of Cincinnati, Cincinnati, OH (Dr. J.J. Monaco, advisor)

Last Updated: 1/5/17