Faculty & Staff at TUC
Shankar J. Chinta
Department: Biological & Pharmaceutical Sciences
Title: Assistant Professor
Fax: (707) 638-5266
Office: Administration & Faculty 2, Rm. 208
Adjunct Faculty, Dominican University of California (2013-2015).
The research interest in my laboratory is to understand the role of various molecular mechanisms that cause nerve cell death associated with Parkinson's disease (PD). We are particularly interested in elucidating the role of mitochondrial dysfunction, protein aggregation, oxidative stress and neuroinflammation. Our ultimate goal is to define the mechanisms that lead to cell death in PD, and then use them as potential targets for drug development.
Rajagopalan S, Rane A, Chinta SJ*, Andersen JK*. Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease. J Neurosci. 2016 Jan 27;36(4):1086-95. *Co-corresponding author.
Siddiqui A, Chinta SJ, Rane A, Rajagopolan S, Lithgow G, Andersen JK Mitochondrial Quality Control via the PGC1alpha-TFEB Signaling Pathway is Compromised by Parkin Q311X Mutation but Independently Restored by Rapamycin. J Neurosci. 2015 Sep 16;35(37):12833-44.
Chinta SJ, Woods G, Rane A, Demaria M, Campisi J, Andersen JK. Cellular senescence and the aging brain. Exp Gerontol. 2014 Oct 1. S0531-5565(14) 00275-7.
Rajagopalan S, Chinta SJ, Andersen JK. Pharmacological prolyl hydroxylase domain inhibition as a therapeutic target for Parkinson's disease. CNS Neurol Disord Drug Targets. 2014 Feb;13(1):120-5.
Chinta SJ, Lieu CA, Demaria M, Laberge RM, Campisi J, Andersen JK. Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease? J Intern Med. 2013 May; 273(5):429-36.
Chinta SJ, Rajagopalan S, Ganesan A and AndersenJK.A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase (PHD) inhibitor 3,4-dihydroxybenzoate (DHB): implications for use as a therapeutic for Parkinson’s disease. Parkinsons Dis. 2012; 2012:364684.
Chinta SJ, and Andersen JK. Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease. Free Radic Res. 2011 Jan; 45(1):53-8.
Chinta SJ, Mallajosyula JK, Rane A, Andersen JK. Mitochondrial alpha-synuclein accumulation impairs Complex I function in dopaminergic neurons and results in increased mitophagy in vivo. Neurosci Lett 2010 Dec 17; 486(3):235-9.
Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG, Polster BM. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med. 2009 Apr 1; 46(7):939-47.
Chinta SJ, Poksay KS, Kaundinya G, Hart M, Bredesen DE, Andersen JK, Rao RV. Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. J Mol Neurosci. 2009 Sep;39(1-2):157-68.
Mallajosyula JK, Kaur D, Chinta SJ, Rajagopalan S, Rane A, Nicholls DG, Di Monte DA, Macarthur H, Andersen JK. MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology. PLoS ONE. 2008 Feb 20;3(2):e1616.
Chinta SJ, Kumar M J, Hsu M, Rajagopalan S, Nicholls DG and Andersen JK. Inducible Depletion of Glutathione Within Adult Dopaminergic Midbrain Neurons Results in Selective Mitochondrial Complex I Inhibition and Age-Related Dopaminergic Nigrostriatal Neurodegeneration. J Neurosci. 2007 Dec 19; 27(51):13997-4006.
Chinta SJ, Kommaddi RP, Turman CM, Strobel HW, Ravindranath V. Constitute expression and localization of Cytochrome P4501A1 in rat and human brain: Presence of splice variant form in human brain. Journal of Neurochemistry. 2005 May; 93(3):724-36.
Chinta, SJ, and Andersen, JK. Oxidant stress susceptibility of dopaminergic neurons: lessons from Parkinson’s disease. Cells in Focus review for special issue. Int J Biochem Cell Biol. 2005, 37(5):942-6.
Pai HV, Kommaddi RP, Chinta SJ, Mori T, Boyd MR, Ravindranath V. (2004). A frame shift mutation and alternate splicing in human brain generates a functional form of the pseudogene, cytochrome P4502D7 that demethylates codeine to morphine. J Biol Chem. 279(26):27383-9.
Chinta SJ, Pai HV, Upadhya SC, Boyd MR, Ravindranath V. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Mol Brain Res Jun 30;103(1-2):49-61.
2013 - 2015 Adjunct Faculty at Dominican University of California, San Rafael.
2008 - 2015 Staff Scientist, Buck Institute for Research on Aging, Novato, CA.
2005 - 2008 Staff Research Investigator, Buck Institute for Research on Aging
2003 - 2005 Postdoctoral Fellow, Buck Institute for Research on Aging
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