Faculty & Staff at TUC
Nathalie Bergeron
College: COP
Department: Biological & Pharmaceutical Sciences
Title: Professor- Chair of Biological and Pharmaceutical Sciences
Phone: (707) 638-5921
Fax: (707) 638-5266
E-Mail: nathalie.bergeron@tu.edu
Office: Administration & Faculty 2, Rm. 112
Laval University, Québec | B.S., R.D. | Health Sciences (Dietetics) | 1985 |
Laval University, Québec | M.S. | Nutrition | 1988 |
Laval University, Québec | Ph.D. | Nutrition | 1992 |
University of California, San Francisco | Postdoc | Nutritional Biochemistry, Physiology | 1996 |
Fall Semester
PHRM 601 & 609: Biological Sciences (Participating Faculty Member)
PHRM 603: Social, Behavioral, and Administrative Sciences (Participating Faculty Member)
PHRM 604 & 612: Clinical Sciences (Participating Faculty Member)
Spring Semester
PHRM 605: Biological Sciences (Course Coordinator)
PHRM 613: Biological Sciences (Participating Faculty Member)
In recent years, there has been a great deal of interest and controversy surrounding
the impact of low-fat high-carbohydrate vs. high-fat low-carbohydrate foods and their
impact on overall health (body weight; plasma lipids; insulin sensitivity; cardiovascular
health). Over the last ten years, my research has focused primarily on how the amount
and quality of dietary fats and carbohydrates affect body composition, as well as
the metabolism of lipoproteins in the fasting and fed (postprandial) state. Another
focus of these studies has been to better understand the physiological determinants
of the postprandial lipid response in individuals with a perturbed metabolism of triglyceride-rich
lipoproteins (visceral obesity; NIDDM, etc.). This research is predominantly clinical
in nature and is ultimately aimed at elucidating the mechanisms whereby diet affects
lipoprotein metabolism and kinetics in both healthy individuals and those at increased
risk for coronary heart disease.
My most recent project in this area is aimed at determining the effects of resistant
vs. rapidly digested starches on blood glucose and insulin responses and on components
of the atherogenic lipoprotein phenotype (ALP), a dyslipidemia associated with obesity,
insulin resistance and diabetes that is characterized by high triglycerides, low HDL
cholesterol, and increased levels of small dense LDL. We hypothesize that a high-carbohydrate
diet consisting primarily of starches that are resistant to enzymatic degradation
by alpha-amylases will improve glycemic control and components of ALP compared to
rapidly digested starches. We further hypothesize that these benefits will be accentuated
when resistant starch is included in a lower-carbohydrate high-fat diet. This 8 week
dietary intervention trial is ongoing and the last participants are expected to complete
the study in Fall of 2011.
We recently launched a dietary intervention trial aimed at assessing whether modification
of the DASH (“Dietary Approaches to Stop Hypertension”) diet by substituting carbohydrate
with fat will result in improvements in multiple biomarkers of CVD risk. Specifically,
we will test the hypotheses that modification of the DASH diet by reducing carbohydrate,
primarily in the form of simple sugars and glycemic starches, and allowing for a more
liberal intake of fat will: (1) improve lipoprotein markers of CVD risk (reduced total/HDL-C,
apolipoprotein B, small LDL particles; and increased HDL-C, apoAI, and large HDL particles);
and (2) result in comparable reductions of systolic and diastolic blood pressure to
those achieved with the standard DASH diet. We will also assess the effects of the
modified DASH diet on markers of insulin resistance and inflammation.
Ultimately these projects are aimed at providing a better understanding of the metabolic
determinants of atherogenic dyslipidemia and its modulation by diet. These clinical
research projects are conducted in collaboration with Dr. Ronald M. Krauss, at Children’s
Hospital Oakland Research Institute.
CURRENTLY HELD AS PRINCIPAL INVESTIGATOR
NIH - R01 Grant (2011-2016)
Bergeron, N. (PI); Krauss, RM (PI; Children’s Hospital Oakland Research Center)
1R01HL106003-01A1, Saturated Fat and Protein Effects on Atherogenic Dyslipidemia.
August 18, 2011-May 31, 2016, Total Direct Cost $$4,675,858
CURRENTLY HELD AS CO-INVESTIGATOR
Dairy Research Institute (2011-2013)
Krauss, RM (PI; Children’s Hospital Oakland Research Center); Bergeron, N. (Co-Investigator)
Effects of a modified, lower carbohydrate higher fat DASH diet plan on plasma lipids,
lipoprotein particle size and blood pressure in healthy adult men. May 1, 2011 - July
31, 2013, Total Direct Costs: $564,266
Almond Board of California (2012-2014) Krauss, RM (PI); Bergeron N. (Co-Investigator); Chui, S. (Co-Investigator) Effects of almond intake on atherogenic dyslipidemia of the metabolic syndrome Total Direct Costs: $440,067
Dairy Research Institute (2013-2015) Krauss, RM (PI); Bergeron N. (Co-Investigator) Effects of Replacing Sugar Sweetened Beverages with Milk on Metabolic Risk Factors in Overweight and Obese Adolescents Total Direct Costs: $247,719
PREVIOUSLY HELD AS PI
NIH RC1 grant (2009-2011)
Bergeron, N. (PI); Krauss, RM (PI; Children’s Hospital Oakland Research Center)
RC1 DK086472A, Effects of resistant starch on lipid and glucose metabolism in insulin
resistance. October 1, 2009- September 30, 2011, Total Direct Cost $624,731
NIH R01 grant (2007-2011)
Bergeron N. (Co-Investigator; PI is J-M Schwarz Touro University CA, College of Osteopathic
Medicine). NIH, R01 R01DK078133 , De Novo Lipogenesis in the Pathogenesis of Non-Alcoholic
Fatty Liver Disease. September 1, 2007 - August 31, 2011), Total Direct Cost $ 1,033,158.
Heart and Stroke Foundation of Canada, Québec (1996-1999)
N. Bergeron. Postprandial response of intestinal and hepatogenenous triglyceride-rich
lipoproteins in visceral obesity. ($16,000/year)
Research Scholar Junior 1/FRSQ-Center (1996-2000)N. Bergeron. Postprandial response of intestinal and hepatogenenous triglyceride-rich
lipoproteins in visceral obesity. ($42,000/year)
Knoll Pharmaceutical Company — The Weight Risk Investigators Study Council (1998-1999)
N. Bergeron, O. Dériaz, JP Després. Metabolic responses to low-fat high complex carbohydrate
vs. high monounsaturated low-fat ($102,600/year)
International Life Sciences Institute Research Foundation (1998-1999)
N. Bergeron, O. Dériaz. Metabolic responses to low-fat high complex carbohydrate vs.
high monounsaturated low-fat diets in obese and non-obese men. ($28,100/year)
Medical Research Council of Canada (1998-2001)
N. Bergeron. Ad libitum feeding of diets varying in the amount of carbohydrate and
fat: Effects on fasting and postprandial lipoproteins in obese men. ($73,137/year)
International Olive Oil Council (1998-2001)
N. Bergeron, O. Dériaz, J.P. Després. Influence of olive oil on postabsorptive and
postprandial lipoproteins, macronutrient intake and oxidation when incorporated into
low-fat vs high-fat diets. ($59,000/year)
PREVIOUSLY HELD AS CO-INVESTIGATOR
American Diabetes Association (2008-2010)
Bergeron N. (Co-Investigator, PI is J-M Schwarz Touro University CA, College of Osteopathic
Medicine). American Diabetes Association 1-08-CR-56, Hepatic and extra-hepatic carbohydrate
metabolism in non-alcoholic fatty liver disease. January 1, 2008 - December 31, 2010),
Total Direct Cost $ 521,739
Dairy Farmers of Canada/NSERC-RII/concerted action FCAR-Novalait-MAPAQ (1999-2001)
Y. Chouinard, N. Bergeron. Mecanisms of synthesis and secretion of conjugated linoleic
acid in dairy cows, and influence of these fatty acids on plasma lipoproteins and
body composition in humans. ($98,000/year)
Dairy Farmers of Canada (1999-2001)
H. Jacques, N. Bergeron. Postprandial lipoprotein response to modified milk fat fractions
of different melting profiles in guinea pigs. ($45,500/year)
Medical Research Council of Canada (1997-2002)
JP Després, J. Bergeron, N. Bergeron, et al. Adipose tissue and lipoprotein metabolism:
A study of genetic and environmental factors involoved in the etiology of the insulin
resistance dyslipidemic syndrome ($103,930/year)
Heart and Stroke Foundation of Canada, Québec (1998-2001)
JP Després, J. Bergeron, N. Bergeron, et al. Adipose tissue and lipoprotein metabolism:
A study of genetic and environmental factors involoved in the etiology of the insulin
resistance dyslipidemic syndrome ($15,000/year)
Medical Research Council of Canada, MRC Groups (10/1998 - 09/2001)
C. Bouchard, J.-A. Simoneau, J.-P. Després, L. Pérusse, D. Prud'Homme, Y. Deshaies,
A. Marette, N. Bergeron, J. Bergeron, Y. C. Chagnon, P. M. Charest, F. T. Dionne,
P. Mauriege, A. Nadeau. The genetics of obesity and its co-morbidities: the Quebec
family study (QFS) ($554,919/année)
FCAR/Research Centre (1999-2002)
D. Richard, Y Deshaies, J.P. Després. A. Tremblay, J.A. Simoneau, C. Bouchard, A.
Marette, N. Bergeron, H. Jacques, O. Dériaz, J. Leblanc, M. Cabanac. (132,500/year)
Canada Foundation for Innovation (1998/2000)
P. Paquin, R. Romain, A. Asselin, D. Michaud, M.-A. Sirard, F. Pothier, C. Lacroix,
J.-P. Després, N. Bergeron, L. Savoie. Research Institute on functional foods and
nutraceuticals. ($17,300,000)
Faghihnia N, Mangravite LM, Chiu S, Bergeron N, Krauss RM. Effects of dietary saturated fat on atherogenic LDL subclasses and apolipoprotein C-III. Eur J Clin Nutr 2012; 66(11):1229-33
Mangravite LM, Chiu S, Wojnoonski K, Rawlings RS, Bergeron N, Krauss RM. Changes in
atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent
on dietary protein source. J Nutrition 2011;141:2139-45
Jacques, H., Leblanc, N., Bergeron, N. Modified milk fat reduces plasma triacylglycerol
concentrations: Health and disease effects. In: De Meester, F., Zibadi, S., Watson,
RR., editors. Modern Dietary Fat Intake in Disease Promotion, New York: Humana Press
2010; Chapter 15, 215-226
Mauger J-F, Lévesque J, Paradis M-E, Bergeron N, Couture P, Lamarche B. Intravascular
kinetics of C-reactive protein and their relationships with features of the metabolic
syndrome. J Clin Endocrinol Metab. 2008;93(8):3158-66
Desroches S, Ruel IL, Deshaies Y, Paradis M-E, Archer WR, Couture P, Bergeron N, Lamarche
B. Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes
in plasma triglyceride levels. Eur J Clin Nutr. 2008 Jan; 62(1):10-17
Paradis M-E, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, Bergeron N,
Lamarche B. Endothelial lipase is associated with inflammation in humans. J Lipid
Res. 2006;47(12):2808-13
Paradis M-E, Hogue, M-O, Mauger J-F, Couillard C, Couture P, Bergeron N, Lamarche
B. Visceral adipose tissue accumulation, secretory phospholipase A2-IIA and atherogenecity
of LDL. Intern J Obes. 2006;30:1615–22
Paradis M-E, Badellino KO, Rader DJ, Tchernof A, Richard C, Luu-The V, Bergeron J,
Archer WR, Couture P, Bergeron N, Lamarche B. Visceral Adiposity and Endothelial Lipase.
J. Clin Endocrin. Metab. 2006;91: 3538-43
Couillard C, Pomerleau S, Ruel G, Archer WR, Bergeron J, Couture P, Lamarche B, Bergeron
N. Associations between hypertriglyceridemia, dietary fat intake, oxidative stress
and endothelial activation in men. Nutrition 2006; Jun;22(6):600-8
Desroches S, Archer WR, Dériaz O, Couture P, Bergeron J, Bergeron N, Lamarche B. Baseline
plasma C-reactive protein concentrations influence lipid and lipoprotein responses
to low-fat and high monounsaturated fatty acid diets in healthy men. J Nutr. 2006
Apr;136(4):1005-11
Mauger JF, Couture P, Bergeron N, Lamarche B. Apolipoprotein C-III isoforms: kinetics
and relative implication in lipid metabolism. J Lipid Res. 2006 Jun;47(6):1212-18
Couillard C, Ruel G, Archer WR, Pomerleau S, Bergeron J, Couture P, Lamarche B, Bergeron
N. Circulating levels of oxidative stress markers and endothelial adhesion molecules
in men with abdominal obesity. J Clin Endocrinol Metab. 2005, 90: 6454–9
Archer WR., Desroches S, Lamarche B, Dériaz O, Landry N, Fontaine-Bisson, B, Bergeron
J, Couture P, Bergeron N. Variations in plasma apoCIII levels are strong correlates
of the triglyceride response to a high-monounsaturated fatty acid diet and a high-carbohydrate
diet. Metabolism 2005;54(10):1390-7
Desroches S, Chouinard PY, Galibois I, Corneau L, Delisle J, Lamarche B, Couture P,
Bergeron N. Lack of effect of dietary conjugated linoleic acids naturally incorporated
into butter on the lipid profile and body composition of overweight and obese men.
Am J Clin Nutr. 2005;82:309-19
Desroches S, Paradis M-E, Perusse M, Archer WR, Bergeron J, Couture P, Bergeron N,
Lamarche B. Apolipoprotein A-I, A-II and VLDL-B-100 metabolism in men: Comparison
of a low fat high carbohydrate diet and a high fat high monounsaturated fatty acid
diet. J Lipid Res. 2004; 45(12):2331-8
Asselin G, Lavigne C, Bergeron N, Angers P, Belkacemi K, Arul J, Jacques H. Fasting
and postprandial lipid response to the consumption of modified milk fats by guinea
pigs. Lipids 2004;39(10):985-92
Archer WR, Lamarche B, St-Pierre AC, Mauger J-F, Dériaz O, Landry N, Corneau L, Després
J-P, Bergeron J, Couture P, Bergeron N. High carbohydrate and high monounsaturated
fatty acid diets similarly affect LDL electrophoretic characteristics in men who are
losing weight J. Nutr. 2003;133:3124-9
Archer WR, Lamarche B, Deriaz O, Landry N, Corneau L, Despres JP, Bergeron J, Couture
P, Bergeron N. Variations in body composition and plasma lipids in response to a high-carbohydrate
diet. Obes Res. 2003;11(8):978-86
Landry N, Bergeron N, Archer R, Samson P, Corneau L, Bergeron J, Deriaz O. Whole body
fat oxidation rate and plsma triacylglycerol concentrations in men consuming an an
libitum high-carbohydrate or low-carbohydrate diet. Am J Clin Nutr. 2003;77:580-6
Couture P, Archer WR, Lamarche B, Landry N, Deriaz O, Corneau L, Bergeron J, Bergeron
N. Influences of apolipoprotein E polymorphism on the response of plasma lipids to
the ad libitum consumption of a high-carbohydrate diet compared with a high-monounsaturated
fatty acid diet. Metabolism 2003;52(11):1454-9
Blackburn P, Lamarche B, Couillard C, Pascot A, Bergeron N, Prud'homme D, Tremblay
A, Bergeron J, Lemieux I, Despres JP. Postprandial hyperlipidemia: another correlate
of the "hypertriglyceridemic waist" phenotype in men. Atherosclerosis. 2003;171(2):327-36
Couillard C, Bergeron N, Pascot A, Alméras N, Bergeron J, Tremblay A, Prud’homme D,
Després J-P. Evidence for impaired lipolysis in abdominally obese men: postprandial
study of apolipoprotein B-48 and B-100-containing lipoproteins. Am J Clin Nutr. 2002;76:311-8
Loe Y-CC., Bergeron N, Rodriguez N, Schwarz J-M. A New Gas Chromatography Mass Spectrometry
Method to Quantify Blood Hydroxycitrate Concentration. Anal Biochem. 2001;292:148-54
Dériaz O, Dumont M, Bergeron N, Després J-P, Prud’homme D. Skeletal muscle low attenuation
area and maximal fat oxidation rate during submaximal exercise in male obese individuals.
Int J Obes Relat Metab Disord. 2001;25(11):1579-84
Couillard C, Bergeron N, Bergeron J, Tremblay A, Prud'homme D, Bouchard C, Després
J-P. Metabolic heterogeneity underlying postprandial lipemia among men with low fasting
plasma HDL cholesterol concentrations. .J Clin Endocrinol Metab. 2000;85(12):4575-82
Dubois L, Girard M, Bergeron N The choice of a diet quality index to measure the health
of a population. Public Health Nutrition 2000;3(3):357-65
Lemieux I, Couillard C, Pascot A, Bergeron N, Prud’homme D, Bergeron J, Tremblay A,
Bouchard C, Mauriège P, J-P Després. The small, dense LDL phenotype of visceral obesity
as a correlate of postprandial lipemia in men. Atheroscelrosis. 2000 Dec;153(2):423-32
Couillard C, Bergeron N, Prud'homme D, Bergeron J, Tremblay A, Bouchard C, Mauriège
P, Després J-P. Gender difference in postprandial lipemia: Importance of visceral
obesity. 1999; Arterioscler. Thromb. Vasc. Biol. 1999;19(10):2448-55
Couillard C, Bergeron N, Prud'homme D, Bergeron J, Tremblay A, Bouchard C, Mauriège
P, Després J-P. Postprandial Triglyceride Response in Visceral Obesity in Men. Diabetes
1998;47(6):953-60
Bergeron N, Kotite L, Verges M, Blanche P, Hamilton R, Krauss R, Bensoudoun A, Havel
RJ. Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient
in apolipoprotein E and hepatic lipase. PNAS 1998;95:15647-52
Qui S, Bergeron N, Kotite L, Krauss R, Bensadoun A, Havel RJ. Concentration, composition
and metabolism of lipoproteins containing apolipoprotein B in hepatic lipase-deficient
mice. J Lipid Res.1998;39(8):1661-8
Bergeron N, Havel RJ. Assessment of Postprandial lipemia: Nutritional Influences.
Current Opin Lipidol. 1997;8(1):43-52
Bergeron N, Havel RJ. Prolonged postprandial responses of lipids and apolipoproteins
in triglyceride-rich lipoproteins in individuals expressing an apolipoprotein e4 allele.
J Clin Invest. 1996;97:65-72
Bergeron N, Kotite L, Havel RJ. Simultaneous Quantification of ApoB-100, ApoB-48,
and ApoE Separated by SDS-PAGE. In: Bradley WA, Gianturco SH, Segrest JP, editors.
Methods in Enzymology: Plasma Lipoproteins, Part C, Quantitation. California: Academic
Press, Inc; 1996;263: p. 82-94
Bergeron N, Havel RJ. Influence of diets rich in saturated and omega-6 polyunsaturated
fatty acids on the postprandial responses of apolipoproteins B48, B100, E, and lipids
in triglyceride-rich lipoproteins. Arterioscler Thromb Vasc Biol. 1995;15:2111-21
Kotite L, Bergeron N, Havel RJ. Quantification of apolipoproteins B-100, B-48 and
E in human triglyceride-rich lipoproteins. J Lipid Res. 1995;36:890-900
Jacques H, Gascon A, Bergeron N, Noreau L, Hurley C, Deshaies Y, Moorjani S, Julien
P. Role of dietary fish protein in the regulation of plasma lipids. Can J Cardiol.
1995; 11: 63G-71G
Bergeron N, Deshaies Y, Jacques H. A factorial experiment to determine the influence
of fish protein and fish oil on serum and liver lipid levels in the rabbit. Nutrition
1992;8(5):354-8
Bergeron N, Deshaies Y, Jacques H. Dietary fish protein modulates HDL-C and lipoprotein
lipase activity in the rabbit. J Nutr. 1992;122:1731-7
Galibois I, Jacques H, Montminy C, Bergeron N, Lavigne C. Independent effects of protein
and fibre sources on glucose and cholesterol metabolism in the rat. Nutr Res. 1992;12:643-55
Bergeron N, Deshaies Y, Lavigne C, Jacques H. Interaction between dietary proteins
and lipids in the regulation of serum and liver lipid levels in the rabbit : Effect
of fish protein. Lipids 1991;26 (9):759-64
Bergeron N, Jacques H. Influence of dietary carbohydrates on cholesterol metabolism
in casein-fed rabbits. Nutr Res, 1990;10:1455-62
Bergeron N, Jacques H. Influence of fish protein as compared to casein and soy protein
on the level of serum and liver lipids and lipoprotein cholesterol distribution in
the rabbit. Atherosclerosis 1989;78:113-21
Other Publications
Bekins, C, Bergeron, N, Breyman, G, Carillo, J, Chen, A, Der, D, Dhanvanthari, L,
Dietz, E, Phillips, J, Gee, S, Hammer, L, Henning, W, Hernried, J, Hufford, D, et
al. Adult Obesity Provider Toolkit. California Medical Association Foundation and
California Association of Health Plans, 2008; 1-106.
Bekins, C, Bergeron, N, Breyman, G, Carillo, J, Chen, A, Der, D, Dhanvanthari, L,
Dietz, E, Phillips, J, Gee, S, Hammer, L, Henning, W, Hernried, J, Hufford, D, et
al. Child and Adolescent Obesity Provider Toolkit. California Medical Association
Foundation and California Association of Health Plans, 2008; 1-85
Bekins, C, Bergeron, N, Breyman, G, Carillo, J, Chen, A, Der, D, Dhanvanthari, L,
Dietz, E, Phillips, J, Gee, S, Hammer, L, Henning, W, Hernried, J, Hufford, D, et
al. Pre/Post-Bariatric Surgery Provider Toolkit. California Medical Association Foundation
and California Association of Health Plans, 2008; 1-18.
American Society for Nutrition
American Association of Colleges of Pharmacy
1992-1996
Heart and Stroke Foundation of Canada, post-doctoral fellowship
1992-1996
Research Institute for the Advancement of Research, post-doctoral fellowship
1992-1996
National Institute of Nutrition, post-doctoral fellowship
1992-1996
Quebec Institute for Health Research, post-doctoral fellowship
1997-1998
Primary Internal Reviewer for Operating Grants from the Heart and Stroke Foundation
of Canada
1998-2001
Primary Internal Reviewer for Operating Grants from the Canadian Diabetes Association
- Applied Grants in Diabetes Education, Management and Care Committee
1998-2000
External Reviewer for Operating Grants from the Heart and Stroke Foundation of Canada
2009-2010
American Association of Colleges of Pharmacy – Academic Leadership Fellows Program
Laval University Hospital/Lipid Research Center | Dietitian | 1986-1989 |
UC San Francisco/Cardiovascular Research Institute | Postgraduate Researcher | 1995-1996 |
Quebec Institute for Health Research | Research Scholar | 1996-2000 |
Laval University/Dept. Food Science & Nutrition | Assistant Research Professor | 1996-2000 |
UC Berkeley/Dept. Nutritional Sciences and Toxicology | Visiting Professor | 2000-2002 |
Laval University/ Dept. Food Science & Nutrition | Adjunct Professor | 2000-2004 |
Touro University – California / College of Pharmacy | Associate Professor | 2005-2011 |
Children's Hospital Oakland Research Institute | Associate Staff Scientist | 2008-present |
Touro University – California / College of Pharmacy | Professor | 2011- |
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