- Touro University, California

Laval University, Québec	B.S., R.D.	Health Sciences (Dietetics)	1985
Laval University, Québec	M.S.	Nutrition	1988
Laval University, Québec	Ph.D.	Nutrition	1992
University of California, San Francisco	Postdoc	Nutritional Biochemistry, Physiology	1996

Fall Semester
PHRM 601 & 609: Biological Sciences (Participating Faculty Member)
PHRM 603: Social, Behavioral, and Administrative Sciences (Participating Faculty Member)
PHRM 604 & 612: Clinical Sciences (Participating Faculty Member)

Spring Semester
PHRM 605: Biological Sciences (Course Coordinator)
PHRM 613: Biological Sciences (Participating Faculty Member)

In recent years, there has been a great deal of interest and controversy surrounding the impact of low-fat high-carbohydrate vs. high-fat low-carbohydrate foods and their impact on overall health (body weight; plasma lipids; insulin sensitivity; cardiovascular health). Over the last ten years, my research has focused primarily on how the amount and quality of dietary fats and carbohydrates affect body composition, as well as the metabolism of lipoproteins in the fasting and fed (postprandial) state. Another focus of these studies has been to better understand the physiological determinants of the postprandial lipid response in individuals with a perturbed metabolism of triglyceride-rich lipoproteins (visceral obesity; NIDDM, etc.). This research is predominantly clinical in nature and is ultimately aimed at elucidating the mechanisms whereby diet affects lipoprotein metabolism and kinetics in both healthy individuals and those at increased risk for coronary heart disease.

My most recent project in this area is aimed at determining the effects of resistant vs. rapidly digested starches on blood glucose and insulin responses and on components of the atherogenic lipoprotein phenotype (ALP), a dyslipidemia associated with obesity, insulin resistance and diabetes that is characterized by high triglycerides, low HDL cholesterol, and increased levels of small dense LDL. We hypothesize that a high-carbohydrate diet consisting primarily of starches that are resistant to enzymatic degradation by alpha-amylases will improve glycemic control and components of ALP compared to rapidly digested starches. We further hypothesize that these benefits will be accentuated when resistant starch is included in a lower-carbohydrate high-fat diet. This 8 week dietary intervention trial is ongoing and the last participants are expected to complete the study in Fall of 2011.

We recently launched a dietary intervention trial aimed at assessing whether modification of the DASH (“Dietary Approaches to Stop Hypertension”) diet by substituting carbohydrate with fat will result in improvements in multiple biomarkers of CVD risk. Specifically, we will test the hypotheses that modification of the DASH diet by reducing carbohydrate, primarily in the form of simple sugars and glycemic starches, and allowing for a more liberal intake of fat will: (1) improve lipoprotein markers of CVD risk (reduced total/HDL-C, apolipoprotein B, small LDL particles; and increased HDL-C, apoAI, and large HDL particles); and (2) result in comparable reductions of systolic and diastolic blood pressure to those achieved with the standard DASH diet. We will also assess the effects of the modified DASH diet on markers of insulin resistance and inflammation.

Ultimately these projects are aimed at providing a better understanding of the metabolic determinants of atherogenic dyslipidemia and its modulation by diet. These clinical research projects are conducted in collaboration with Dr. Ronald M. Krauss, at Children’s Hospital Oakland Research Institute.

CURRENTLY HELD AS PRINCIPAL INVESTIGATOR
NIH RC1 grant (2009-2011)
Bergeron, N. (PI); Krauss, RM (PI; Children’s Hospital Oakland Research Center)
RC1 DK086472A, Effects of resistant starch on lipid and glucose metabolism in insulin resistance. October 1, 2009- September 30, 2011, Total Direct Cost $624,731

NIH - R01 Grant (2011-2016)
Bergeron, N. (PI); Krauss, RM (PI; Children’s Hospital Oakland Research Center)
1R01HL106003-01A1, Saturated Fat and Protein Effects on Atherogenic Dyslipidemia. August 18, 2011-May 31, 2016, Total Direct Cost $$4,675,858

CURRENTLY HELD AS CO-INVESTIGATOR
Dairy Research Institute (2011-2013)
Krauss, RM (PI; Children’s Hospital Oakland Research Center); Bergeron, N. (Co-Investigator)
Effects of a modified, lower carbohydrate higher fat DASH diet plan on plasma lipids, lipoprotein particle size and blood pressure in healthy adult men. May 1, 2011 - July 31, 2013, Total Direct Costs: $564,266

NIH R01 grant (2007-2011)
Bergeron N. (Co-Investigator; PI is J-M Schwarz Touro University CA, College of Osteopathic Medicine). NIH, R01 R01DK078133 , De Novo Lipogenesis in the Pathogenesis of Non-Alcoholic Fatty Liver Disease. September 1, 2007 - August 31, 2011), Total Direct Cost $ 1,033,158.

PREVIOUSLY HELD AS PI
Heart and Stroke Foundation of Canada, Québec (1996-1999)
N. Bergeron. Postprandial response of intestinal and hepatogenenous triglyceride-rich lipoproteins in visceral obesity. ($16,000/year)

Research Scholar Junior 1/FRSQ-Center (1996-2000)N. Bergeron. Postprandial response of intestinal and hepatogenenous triglyceride-rich lipoproteins in visceral obesity. ($42,000/year)

Knoll Pharmaceutical Company — The Weight Risk Investigators Study Council (1998-1999)
N. Bergeron, O. Dériaz, JP Després. Metabolic responses to low-fat high complex carbohydrate vs. high monounsaturated low-fat ($102,600/year)

International Life Sciences Institute Research Foundation (1998-1999)
N. Bergeron, O. Dériaz. Metabolic responses to low-fat high complex carbohydrate vs. high monounsaturated low-fat diets in obese and non-obese men. ($28,100/year)

Medical Research Council of Canada (1998-2001)
N. Bergeron. Ad libitum feeding of diets varying in the amount of carbohydrate and fat: Effects on fasting and postprandial lipoproteins in obese men. ($73,137/year)

International Olive Oil Council (1998-2001)
N. Bergeron, O. Dériaz, J.P. Després. Influence of olive oil on postabsorptive and postprandial lipoproteins, macronutrient intake and oxidation when incorporated into low-fat vs high-fat diets. ($59,000/year)

PREVIOUSLY HELD AS CO-INVESTIGATOR
American Diabetes Association (2008-2010)
Bergeron N. (Co-Investigator, PI is J-M Schwarz Touro University CA, College of Osteopathic Medicine). American Diabetes Association 1-08-CR-56, Hepatic and extra-hepatic carbohydrate metabolism in non-alcoholic fatty liver disease. January 1, 2008 - December 31, 2010), Total Direct Cost $ 521,739

Dairy Farmers of Canada/NSERC-RII/concerted action FCAR-Novalait-MAPAQ (1999-2001)
Y. Chouinard, N. Bergeron. Mecanisms of synthesis and secretion of conjugated linoleic acid in dairy cows, and influence of these fatty acids on plasma lipoproteins and body composition in humans. ($98,000/year)

Dairy Farmers of Canada (1999-2001)
H. Jacques, N. Bergeron. Postprandial lipoprotein response to modified milk fat fractions of different melting profiles in guinea pigs. ($45,500/year)

Medical Research Council of Canada (1997-2002)
JP Després, J. Bergeron, N. Bergeron, et al. Adipose tissue and lipoprotein metabolism: A study of genetic and environmental factors involoved in the etiology of the insulin resistance dyslipidemic syndrome ($103,930/year)

Heart and Stroke Foundation of Canada, Québec (1998-2001)
JP Després, J. Bergeron, N. Bergeron, et al. Adipose tissue and lipoprotein metabolism: A study of genetic and environmental factors involoved in the etiology of the insulin resistance dyslipidemic syndrome ($15,000/year)

Medical Research Council of Canada, MRC Groups (10/1998 - 09/2001)
C. Bouchard, J.-A. Simoneau, J.-P. Després, L. Pérusse, D. Prud'Homme, Y. Deshaies, A. Marette, N. Bergeron, J. Bergeron, Y. C. Chagnon, P. M. Charest, F. T. Dionne, P. Mauriege, A. Nadeau. The genetics of obesity and its co-morbidities: the Quebec family study (QFS) ($554,919/année)

FCAR/Research Centre (1999-2002)
D. Richard, Y Deshaies, J.P. Després. A. Tremblay, J.A. Simoneau, C. Bouchard, A. Marette, N. Bergeron, H. Jacques, O. Dériaz, J. Leblanc, M. Cabanac. (132,500/year)

Canada Foundation for Innovation (1998/2000)
P. Paquin, R. Romain, A. Asselin, D. Michaud, M.-A. Sirard, F. Pothier, C. Lacroix, J.-P. Després, N. Bergeron, L. Savoie. Research Institute on functional foods and nutraceuticals. ($17,300,000)

Mangravite LM, Chiu S, Wojnoonski K, Rawlings RS, Bergeron N, Krauss RM. Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein source. J Nutrition 2011;141:2139-45

Jacques, H., Leblanc, N., Bergeron, N. Modified milk fat reduces plasma triacylglycerol concentrations: Health and disease effects. In: De Meester, F., Zibadi, S., Watson, RR., editors. Modern Dietary Fat Intake in Disease Promotion, New York: Humana Press 2010; Chapter 15, 215-226

Mauger J-F, Lévesque J, Paradis M-E, Bergeron N, Couture P, Lamarche B. Intravascular kinetics of C-reactive protein and their relationships with features of the metabolic syndrome. J Clin Endocrinol Metab. 2008;93(8):3158-66

Desroches S, Ruel IL, Deshaies Y, Paradis M-E, Archer WR, Couture P, Bergeron N, Lamarche B. Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels. Eur J Clin Nutr. 2008 Jan; 62(1):10-17

Paradis M-E, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, Bergeron N, Lamarche B. Endothelial lipase is associated with inflammation in humans. J Lipid Res. 2006;47(12):2808-13

Paradis M-E, Hogue, M-O, Mauger J-F, Couillard C, Couture P, Bergeron N, Lamarche B. Visceral adipose tissue accumulation, secretory phospholipase A2-IIA and atherogenecity of LDL. Intern J Obes. 2006;30:1615–22

Paradis M-E, Badellino KO, Rader DJ, Tchernof A, Richard C, Luu-The V, Bergeron J, Archer WR, Couture P, Bergeron N, Lamarche B. Visceral Adiposity and Endothelial Lipase. J. Clin Endocrin. Metab. 2006;91: 3538-43

Couillard C, Pomerleau S, Ruel G, Archer WR, Bergeron J, Couture P, Lamarche B, Bergeron N. Associations between hypertriglyceridemia, dietary fat intake, oxidative stress and endothelial activation in men. Nutrition 2006; Jun;22(6):600-8

Desroches S, Archer WR, Dériaz O, Couture P, Bergeron J, Bergeron N, Lamarche B. Baseline plasma C-reactive protein concentrations influence lipid and lipoprotein responses to low-fat and high monounsaturated fatty acid diets in healthy men. J Nutr. 2006 Apr;136(4):1005-11

Mauger JF, Couture P, Bergeron N, Lamarche B. Apolipoprotein C-III isoforms: kinetics and relative implication in lipid metabolism. J Lipid Res. 2006 Jun;47(6):1212-18

Couillard C, Ruel G, Archer WR, Pomerleau S, Bergeron J, Couture P, Lamarche B, Bergeron N. Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab. 2005, 90: 6454–9

Archer WR., Desroches S, Lamarche B, Dériaz O, Landry N, Fontaine-Bisson, B, Bergeron J, Couture P, Bergeron N. Variations in plasma apoCIII levels are strong correlates of the triglyceride response to a high-monounsaturated fatty acid diet and a high-carbohydrate diet. Metabolism 2005;54(10):1390-7

Desroches S, Chouinard PY, Galibois I, Corneau L, Delisle J, Lamarche B, Couture P, Bergeron N. Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men. Am J Clin Nutr. 2005;82:309-19

Desroches S, Paradis M-E, Perusse M, Archer WR, Bergeron J, Couture P, Bergeron N, Lamarche B. Apolipoprotein A-I, A-II and VLDL-B-100 metabolism in men: Comparison of a low fat high carbohydrate diet and a high fat high monounsaturated fatty acid diet. J Lipid Res. 2004; 45(12):2331-8

Asselin G, Lavigne C, Bergeron N, Angers P, Belkacemi K, Arul J, Jacques H. Fasting and postprandial lipid response to the consumption of modified milk fats by guinea pigs. Lipids 2004;39(10):985-92

Archer WR, Lamarche B, St-Pierre AC, Mauger J-F, Dériaz O, Landry N, Corneau L, Després J-P, Bergeron J, Couture P, Bergeron N. High carbohydrate and high monounsaturated fatty acid diets similarly affect LDL electrophoretic characteristics in men who are losing weight J. Nutr. 2003;133:3124-9

Archer WR, Lamarche B, Deriaz O, Landry N, Corneau L, Despres JP, Bergeron J, Couture P, Bergeron N. Variations in body composition and plasma lipids in response to a high-carbohydrate diet. Obes Res. 2003;11(8):978-86

Landry N, Bergeron N, Archer R, Samson P, Corneau L, Bergeron J, Deriaz O. Whole body fat oxidation rate and plsma triacylglycerol concentrations in men consuming an an libitum high-carbohydrate or low-carbohydrate diet. Am J Clin Nutr. 2003;77:580-6

Couture P, Archer WR, Lamarche B, Landry N, Deriaz O, Corneau L, Bergeron J, Bergeron N. Influences of apolipoprotein E polymorphism on the response of plasma lipids to the ad libitum consumption of a high-carbohydrate diet compared with a high-monounsaturated fatty acid diet. Metabolism 2003;52(11):1454-9

Blackburn P, Lamarche B, Couillard C, Pascot A, Bergeron N, Prud'homme D, Tremblay A, Bergeron J, Lemieux I, Despres JP. Postprandial hyperlipidemia: another correlate of the "hypertriglyceridemic waist" phenotype in men. Atherosclerosis. 2003;171(2):327-36

Couillard C, Bergeron N, Pascot A, Alméras N, Bergeron J, Tremblay A, Prud’homme D, Després J-P. Evidence for impaired lipolysis in abdominally obese men: postprandial study of apolipoprotein B-48 and B-100-containing lipoproteins. Am J Clin Nutr. 2002;76:311-8

Loe Y-CC., Bergeron N, Rodriguez N, Schwarz J-M. A New Gas Chromatography Mass Spectrometry Method to Quantify Blood Hydroxycitrate Concentration. Anal Biochem. 2001;292:148-54

Dériaz O, Dumont M, Bergeron N, Després J-P, Prud’homme D. Skeletal muscle low attenuation area and maximal fat oxidation rate during submaximal exercise in male obese individuals. Int J Obes Relat Metab Disord. 2001;25(11):1579-84

Couillard C, Bergeron N, Bergeron J, Tremblay A, Prud'homme D, Bouchard C, Després J-P. Metabolic heterogeneity underlying postprandial lipemia among men with low fasting plasma HDL cholesterol concentrations. .J Clin Endocrinol Metab. 2000;85(12):4575-82

Dubois L, Girard M, Bergeron N The choice of a diet quality index to measure the health of a population. Public Health Nutrition 2000;3(3):357-65

Lemieux I, Couillard C, Pascot A, Bergeron N, Prud’homme D, Bergeron J, Tremblay A, Bouchard C, Mauriège P, J-P Després. The small, dense LDL phenotype of visceral obesity as a correlate of postprandial lipemia in men. Atheroscelrosis. 2000 Dec;153(2):423-32

Couillard C, Bergeron N, Prud'homme D, Bergeron J, Tremblay A, Bouchard C, Mauriège P, Després J-P. Gender difference in postprandial lipemia: Importance of visceral obesity. 1999; Arterioscler. Thromb. Vasc. Biol. 1999;19(10):2448-55

Couillard C, Bergeron N, Prud'homme D, Bergeron J, Tremblay A, Bouchard C, Mauriège P, Després J-P. Postprandial Triglyceride Response in Visceral Obesity in Men. Diabetes 1998;47(6):953-60

Bergeron N, Kotite L, Verges M, Blanche P, Hamilton R, Krauss R, Bensoudoun A, Havel RJ. Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase. PNAS 1998;95:15647-52

Qui S, Bergeron N, Kotite L, Krauss R, Bensadoun A, Havel RJ. Concentration, composition and metabolism of lipoproteins containing apolipoprotein B in hepatic lipase-deficient mice. J Lipid Res.1998;39(8):1661-8

Bergeron N, Havel RJ. Assessment of Postprandial lipemia: Nutritional Influences. Current Opin Lipidol. 1997;8(1):43-52

Bergeron N, Havel RJ. Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins in individuals expressing an apolipoprotein e4 allele. J Clin Invest. 1996;97:65-72

Bergeron N, Kotite L, Havel RJ. Simultaneous Quantification of ApoB-100, ApoB-48, and ApoE Separated by SDS-PAGE. In: Bradley WA, Gianturco SH, Segrest JP, editors. Methods in Enzymology: Plasma Lipoproteins, Part C, Quantitation. California: Academic Press, Inc; 1996;263: p. 82-94

Bergeron N, Havel RJ. Influence of diets rich in saturated and omega-6 polyunsaturated fatty acids on the postprandial responses of apolipoproteins B48, B100, E, and lipids in triglyceride-rich lipoproteins. Arterioscler Thromb Vasc Biol. 1995;15:2111-21

Kotite L, Bergeron N, Havel RJ. Quantification of apolipoproteins B-100, B-48 and E in human triglyceride-rich lipoproteins. J Lipid Res. 1995;36:890-900

Jacques H, Gascon A, Bergeron N, Noreau L, Hurley C, Deshaies Y, Moorjani S, Julien P. Role of dietary fish protein in the regulation of plasma lipids. Can J Cardiol. 1995; 11: 63G-71G

Bergeron N, Deshaies Y, Jacques H. A factorial experiment to determine the influence of fish protein and fish oil on serum and liver lipid levels in the rabbit. Nutrition 1992;8(5):354-8

Bergeron N, Deshaies Y, Jacques H. Dietary fish protein modulates HDL-C and lipoprotein lipase activity in the rabbit. J Nutr. 1992;122:1731-7

Galibois I, Jacques H, Montminy C, Bergeron N, Lavigne C. Independent effects of protein and fibre sources on glucose and cholesterol metabolism in the rat. Nutr Res. 1992;12:643-55

Bergeron N, Deshaies Y, Lavigne C, Jacques H. Interaction between dietary proteins and lipids in the regulation of serum and liver lipid levels in the rabbit : Effect of fish protein. Lipids 1991;26 (9):759-64

Bergeron N, Jacques H. Influence of dietary carbohydrates on cholesterol metabolism in casein-fed rabbits. Nutr Res, 1990;10:1455-62

Bergeron N, Jacques H. Influence of fish protein as compared to casein and soy protein on the level of serum and liver lipids and lipoprotein cholesterol distribution in the rabbit. Atherosclerosis 1989;78:113-21

Other Publications

Bekins, C, Bergeron, N, Breyman, G, Carillo, J, Chen, A, Der, D, Dhanvanthari, L, Dietz, E, Phillips, J, Gee, S, Hammer, L, Henning, W, Hernried, J, Hufford, D, et al. Adult Obesity Provider Toolkit. California Medical Association Foundation and California Association of Health Plans, 2008; 1-106.

Bekins, C, Bergeron, N, Breyman, G, Carillo, J, Chen, A, Der, D, Dhanvanthari, L, Dietz, E, Phillips, J, Gee, S, Hammer, L, Henning, W, Hernried, J, Hufford, D, et al. Child and Adolescent Obesity Provider Toolkit. California Medical Association Foundation and California Association of Health Plans, 2008; 1-85

Bekins, C, Bergeron, N, Breyman, G, Carillo, J, Chen, A, Der, D, Dhanvanthari, L, Dietz, E, Phillips, J, Gee, S, Hammer, L, Henning, W, Hernried, J, Hufford, D, et al. Pre/Post-Bariatric Surgery Provider Toolkit. California Medical Association Foundation and California Association of Health Plans, 2008; 1-18.

Quebec Dietetic Association
American Association of Colleges of Pharmacy

1992-1996
Heart and Stroke Foundation of Canada, post-doctoral fellowship

1992-1996
Research Institute for the Advancement of Research, post-doctoral fellowship

1992-1996
National Institute of Nutrition, post-doctoral fellowship

1992-1996
Quebec Institute for Health Research, post-doctoral fellowship

1997-1998
Primary Internal Reviewer for Operating Grants from the Heart and Stroke Foundation of Canada

1998-2001
Primary Internal Reviewer for Operating Grants from the Canadian Diabetes Association - Applied Grants in Diabetes Education, Management and Care Committee

1998-2000
External Reviewer for Operating Grants from the Heart and Stroke Foundation of Canada

2009-2010
American Association of Colleges of Pharmacy – Academic Leadership Fellows Program

Laval University Hospital/Lipid Research Center	Dietitian	1986-1989
UC San Francisco/Cardiovascular Research Institute	Postgraduate Researcher	1995-1996
Quebec Institute for Health Research	Research Scholar	1996-2000
Laval University/Dept. Food Science & Nutrition	Assistant Research Professor	1996-2000
UC Berkeley/Dept. Nutritional Sciences and Toxicology	Visiting Professor	2000-2002
Laval University/ Dept. Food Science & Nutrition	Adjunct Professor	2000-2004
Touro University – California / College of Pharmacy	Associate Professor	2005-2011
Children's Hospital Oakland Research Institute	Associate Staff Scientist	2008-present
Touro University – California / College of Pharmacy	Professor	2011-

Faculty & Staff at TUC

Nathalie Bergeron